Neuron directional growth and nerve terahertz signal excitation integrated chip

Abstract

The invention discloses a neuron directional growth and nerve terahertz signal excitation integrated chip, which comprises a sensing chip unit and a microfluidic cell culture unit. The sensing chip unit comprises a silicon dioxide substrate and a gold film layer, the gold film layer is etched with a nanopore periodic array structure, the nanopore periodic array structure is composed of multiple groups of double nanopores which are arranged in a periodic array, the gold film layer is combined with a micron-sized microfluidic channel to form an area for controlling the growth of neurons, and the growth of the neurons in some directions is stopped or promoted by using the micro mechanical force of a special microfluidic channel structure. The growth speed of the neurons is further regulated and controlled by using an external terahertz electromagnetic signal and a biological guidance factor. According to the invention, directional growth of neuronal axons in the micro-nano precision of the sensing chip is realized, the nanopore part of a sensing element and neuronal protein molecules to be detected are positioned in nano precision, and integration of excitation and detection of terahertz signals, acoustic signals and electric signals in nerve cell culture is realized.

Description

Technical field[0001]The present invention relates to the field of biological terahertz detection, and in particular, to a neuron directional growth and a nerve terahertz signal excitation integrated chip.Background technique[0002]The brain is composed of numerous nerve cells and gum cells, and the nerve cells are passed through an axon, and the dendritic formation of synaptic (including chemical syntax, electrical touch), and the information transfer of each other is achieved, and numerous nerve cells constitute a huge Neural network, thus synapsed signal detection is essential for signal processing in the brain. At present, the research on the human brain is mostly based on the EMO genus, and the measured electrical signal is in the KHz range, which does not meet the requirements of high-speed high bandwidth signals such as high-speed high-band width signals. Theoretical proves that human brain nerve cells have a large number of terahertz information, but it is difficult to achiev...

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Problems solved by technology

[0003] Although there are currently many studies on the construction of synapses by culturing neurons in vitro with microfluidic chips, as well as co-cultivation experiments of neurons and glial cells, all of them are nerve cell culture chambers separated from nerve signal detection devices, and it is impossible to achieve cell culture and glial cell culture. Signal detection is integrated; and the experiment cannot complete the directional growth of neuron axons at micro-nano precision, and the myelination of neuron axons, and cannot be fixed-point positioned in the solution to stimulate nerve terahertz signal generation, and detection in solution cannot be realized

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