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Method for simultaneously detecting ammonia and acetone in exhaled gas on line

A technology of exhaled gas and acetone, which is applied in the preparation of test samples, measuring devices, and material analysis through electromagnetic means, and can solve problems such as long response time, inapplicable on-site rapid detection of exhaled acetone, and single detection

Active Publication Date: 2021-06-08
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

In addition, chemical ionization mass spectrometers such as proton transfer mass spectrometry and selected ion flow tube mass spectrometry are used to detect the concentration of acetone in exhaled breath in real time. On-site Rapid Detection of Exhaled Acetone

Method used

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  • Method for simultaneously detecting ammonia and acetone in exhaled gas on line
  • Method for simultaneously detecting ammonia and acetone in exhaled gas on line
  • Method for simultaneously detecting ammonia and acetone in exhaled gas on line

Examples

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Embodiment 1

[0023] Using a semiconductor refrigeration device combined with a real-time online ion mobility spectrometer, the exhaled breath of volunteer 1 was analyzed and detected. Volunteer 1 was male, 55 years old, 175 cm tall, and 60 kg in weight. Firstly, the exhaled breath of volunteer 1 was collected in a 1-3L Tedlar air bag, and then the exhaled air in the air bag was collected in real time by a real-time online ion mobility spectrometer, and the semiconductor refrigeration device was used to obtain the following: figure 2 Ion mobility spectra are shown for the detection of ammonia and acetone in exhaled breath. The mechanism of the reaction: the reagent ion is H 3 o + , the corresponding migration time is 2.70ms, and the reduced mobility is 2.31 cm 2 V -1 the s -1 . At room temperature, the semiconductor refrigeration does not heat, and the exhaled breath is collected in real time. Because the proton affinity of ammonia is relatively large, it can be combined with the rea...

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Abstract

The invention discloses a method for simultaneously detecting ammonia and acetone in exhaled gas on line. The method is characterized in that an online ion mobility spectrometer is combined with a semiconductor refrigeration device, a sample gas flow is continuously sampled by the semiconductor refrigeration device and the ion mobility spectrometer at room temperature to realize accurate quantitative detection of ammonia in the exhaled gas; after the semiconductor refrigeration is stable, the sample gas flow passes through the semiconductor refrigeration device which is lower than room temperature and is at a stable temperature value, and the ion mobility spectrometer continuously samples to realize accurate quantitative detection of acetone in exhaled gas; in the semiconductor refrigeration process, the sample gas flow passes through the semiconductor refrigeration device which starts to cool at room temperature, and the ion mobility spectrometer continuously samples and simultaneously realizes online detection of ammonia and acetone in exhaled gas; and the semiconductor refrigeration device effectively eliminates the interference of humidity in exhaled air, improves the sensitivity of online detection of acetone in exhaled air, and realizes simultaneous online detection of ppbv-magnitude exhaled air ammonia and acetone in exhaled air.

Description

technical field [0001] Based on the ion mobility spectrometry technology and combined with a semiconductor refrigeration device, the invention eliminates the influence of humidity in exhaled air, realizes the simultaneous detection of ammonia and acetone in exhaled air, and can be used for the diagnosis of exhaled air-related diseases. Background technique [0002] The detection speed of ion mobility spectrometry is fast and the sensitivity is high, but it is easily affected by other interferences, such as the humidity in the exhaled air. In addition, ion mobility spectrometry is difficult to measure multi-component compounds simultaneously, and two compounds usually undergo competitive ionization, affecting each other's ionization efficiency and accurate quantification. [0003] Huang Honghu et al. used a nanosensor to detect acetone in exhaled air, using the nanomolecular sieve material Ag + As a sensitive film, ZSM-5 is combined with a piezoelectric resonant mass sensor ...

Claims

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Application Information

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IPC IPC(8): G01N27/622G01N1/42
CPCG01N27/62G01N1/42
Inventor 蒋丹丹李海洋黄卫李杭厉梅
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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