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Application of cannabidiol-3-sulfonic acid in the preparation of drugs for preventing and/or treating inflammation-related diseases

An inflammation-related disease, cannabidiol technology, applied in the direction of active ingredients of anhydride/acid/halide, drug combination, and resistance to vector-borne diseases, etc., can solve problems such as poor selectivity, obvious side effects, and clinical application limitations, and achieve good results Effect of water solubility and high anti-inflammatory properties

Active Publication Date: 2022-06-03
YANTAI HEMP BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor selectivity of traditional anti-inflammatory drugs, obvious side effects, and limited clinical application, the research and development of new anti-inflammatory drugs has always been the focus of new drug research

Method used

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  • Application of cannabidiol-3-sulfonic acid in the preparation of drugs for preventing and/or treating inflammation-related diseases
  • Application of cannabidiol-3-sulfonic acid in the preparation of drugs for preventing and/or treating inflammation-related diseases
  • Application of cannabidiol-3-sulfonic acid in the preparation of drugs for preventing and/or treating inflammation-related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of cannabidiol-3-sulfonic acid injection

[0025] prescription:

[0026]

[0027] Operation: Take about 800 mL of water for injection, add sodium chloride and cannabidiol-3-sulfonic acid, stir to dissolve, add 0.1 mol / L sodium hydroxide solution to adjust the pH to 6.5-7.0, add water to a sufficient amount, stir Evenly, filter and dispense into 1mL ampoules, seal with nitrogen, and sterilize by circulating steam at 100°C for 30min.

Embodiment 2

[0029] Preparation of cannabidiol-3-sulfonic acid freeze-dried powder for injection

[0030] prescription:

[0031]

[0032] Operation: Take about 1600 mL of water for injection, add cannabidiol-3-sulfonic acid, mannitol, EDTA-2Na, stir to dissolve, add 0.1 mol / L sodium hydroxide solution to adjust the pH to 6.5-7.0, and add water until enough amount, stir well, filter and dispense into ampoules of 2ml each, freeze-dry and seal, and check for air leakage.

Embodiment 3

[0034] Preparation of cannabidiol-3-sulfonic acid eye drops

[0035] prescription:

[0036]

[0037] Operation: Take about 800mL of distilled water, add cannabidiol-3-sulfonic acid, sodium chloride, methylparaben, stir to dissolve, add 0.1mol / L sodium hydroxide solution to adjust pH to 6.5-7.0, add water To a sufficient amount, stir evenly, filter and fill, and sterilize by circulating steam at 100 °C for 30 minutes.

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PUM

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Abstract

The invention provides the application of cannabidiol-3-sulfonic acid in the preparation of drugs for preventing and / or treating inflammation-related diseases, and belongs to the technical field of anti-inflammatory drugs. The application of cannabidiol-3-sulfonic acid with structural formula as shown in formula I in the preparation of drugs for the prevention and / or treatment of inflammation-related diseases; the cannabidiol-3-sulfonic acid not only has high water solubility, but also has Compared with cannabidiol, it has stronger anti-inflammatory activity. Through in vitro inflammation model experiments, it was found that cannabidiol-3-sulfonic acid can significantly inhibit the mRNA expression levels of inflammatory factors IL-1β, IL-6 and iNOS, confirming that the compound has obvious anti-inflammatory effects and can be used for the preparation of therapeutic and Drugs for the prevention of inflammation-related diseases.

Description

technical field [0001] The invention belongs to the technical field of anti-inflammatory drugs, in particular to the application of cannabidiol-3-sulfonic acid in the preparation of drugs for preventing and / or treating inflammation-related diseases. Background technique [0002] Inflammation is a common clinical pathological process, and it is a complex defense response of biological organisms with vascular system to damage factors (such as allergic reactions produced by bacteria, viruses, antigens and nuclear antibodies, etc.) parts of tissues and organs. When pro-inflammatory factors act on the body, the body eliminates the pro-inflammatory factors through an inflammatory response, which is a process of injury and anti-injury. Many common diseases, such as folliculitis, tonsillitis, pneumonia, hepatitis, pancreatitis, nephritis, etc., as well as autoimmune diseases, atherosclerosis, wound repair, etc., belong to the category of inflammation. Anti-inflammatory drugs are t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/185A61P29/00
CPCA61K31/185A61P29/00Y02A50/30
Inventor 曲桂武崔明
Owner YANTAI HEMP BIOTECHNOLOGY CO LTD