Application of anti-inflammatory active ingredient of blumea balsamifera in medicines

A kind of technology of enamel and its active ingredients, which is applied in the field of medicine and can solve the problems that there is no patent application for the anti-inflammatory active ingredients of enamel

Inactive Publication Date: 2021-06-22
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Application of anti-inflammatory active ingredient of blumea balsamifera in medicines
  • Application of anti-inflammatory active ingredient of blumea balsamifera in medicines
  • Application of anti-inflammatory active ingredient of blumea balsamifera in medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] Example Determining the Effective Dose of Enarin

[0023] Select 5×10 5 A / ml density was added to 24-well plate, 500 μl / well, and after 12 hours of culture, the blank group, LPS (800ng / ml), and various doses of enamelin (1, 5, 10, 20, 40, 80 μg / ml) were set up. +LPS group, each group has 3 replicate wells. After culturing for 12 hours, the cell supernatant was collected and operated according to the ELISA instructions. The absorbance value was detected at 450 nm, and the IL-6 content was calculated with reference to the standard curve.

[0024] The result is as Figure 9 As shown, ainasarin can inhibit the secretion of cytokine IL-6 in the dose range of 5μg / ml-80μg / ml, and then according to the results of cytotoxicity, choose 5μg / ml, 10μg / ml, 20μg / ml three Dosage for later experiments.

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Abstract

The invention discloses application of an anti-inflammatory active ingredient of blumea balsamifera in medicines, relates to medicines, and provides influence of the anti-inflammatory active ingredient of blumea balsamifera on expression and phosphorylation level of nuclear transcription factor NF-kB related proteins I kB alpha and p65 and on cell nucleus displacement. The anti-inflammatory activity of the blumea balsamifera is confirmed, the dosage of the blumea balsamifera applied to the medicine is determined to be 5-80 mu g/ml, and a foundation is laid for the application of the anti-inflammatory active component in the medicine.

Description

technical field [0001] The invention relates to medicine, in particular to the application of the anti-inflammatory active ingredient of ainasin in medicine. Background technique [0002] Ainafrasin ( blumeatin ) is the extract of the plant Ainaxiang, its molecular formula is C16H14O6, the molecular weight is 302.27876, and the CAS number is 118024-26-3; Ainaxiang is a light yellow crystalline powder, soluble in methanol, ethanol, ethyl acetate, slightly soluble In petroleum ether, insoluble in water. The preparation method usually uses Ainaxiang medicinal material as raw material, and it is obtained through decolorization and degreasing, preparation of extract, preparation of imprinted template, extraction and separation, and purification of preparative liquid phase. At present, ainasarin is mainly used as a drug for the treatment or prevention of hypersensitivity diseases. [0003] In the Chinese patent database, the patents related to ainasin are: No. ZL2008100447999 "...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P29/00A61K36/28
CPCA61K31/352A61P29/00A61K36/28
Inventor 王鲁彭俊超杨会龙莉
Owner GUIZHOU UNIV
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