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Composition with sedative and sleep-aiding effects and application thereof

A technology of composition and efficacy, applied in the field of medicine, can solve problems such as poor and adverse reaction effects, and achieve the effect of high safety

Inactive Publication Date: 2021-06-22
HEMPIRE (SHANGHAI) PHARM R&D LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to solve the problem that the existing compositions with sedative and sleep-promoting functions will cause serious adverse reactions or poor effects, and provide a kind of active substance that uses CBD, CBN and THC, and the three are in a specific ratio range at the same time. Existing composition, each component of the composition exhibits synergistic effect with each other, and has significant sedative and sleep-promoting effects

Method used

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  • Composition with sedative and sleep-aiding effects and application thereof
  • Composition with sedative and sleep-aiding effects and application thereof
  • Composition with sedative and sleep-aiding effects and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0042] 2.1.1 Preparation of test liquid:

[0043] Preparation of blank milk: Weigh 25g of glycerin and dissolve it in 500ml of water for injection, weigh 12g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly until a stable fat emulsion submicroemulsion solution is formed. Filter through a microporous membrane, aliquot, spin sterilize, and use as blank milk.

[0044]Preparation of CBD sub-microemulsion: Weigh 25g of glycerin and dissolve it in 500ml of water for injection, weigh 12g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.0943g of CBD crystals and dissolve it in 100g In coconut oil, add 2g of oleic acid and mix well to obtain a CBD oil solution; add the CBD oil solution into a high-shear emulsifier at a constant speed to prepare a fat emulsion solution, and add water for injection to 1000ml until a stable fat...

Embodiment 1-3 and comparative example 1-4

[0066] Weigh 250g of glycerin and dissolve it in 5000ml of water for injection, weigh 120g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.2563g of CBD crystals, 0.0431g of THC crystals, and 0.0864g of CBN crystals Dissolve in 1000g (400g of sweet almond oil, 300g of coconut oil, 300g of linseed oil) mixed oil, add 20g of oleic acid and mix to obtain an oil phase; add the oil phase into a high-shear emulsifier at a uniform speed to prepare a fat emulsion solution , add water for injection to 10000ml, until a stable fat emulsion submicroemulsion solution is formed, filter through a microporous membrane, subpackage, and spin sterilize, as the test drug solution of Example 2, the content of CBD is 0.02559mg / ml, THC Content of 0.00428mg / ml, CBN content of 0.00856mg / ml (ratio about 6:1:2); according to this method to prepare other examples and comparative examples for testing liquid.

[006...

Embodiment 4-6 and comparative example 5-8

[0112] Weigh 250g of glycerin and dissolve it in 5000ml of water for injection, weigh 120g of soybean lecithin and disperse it in the glycerin solution, and place it in a high-shear emulsifier to disperse evenly; accurately weigh 0.2563g of CBD crystals, 0.0431g of THC crystals, and 0.0864g of CBN crystals Dissolve in 1000g (400g of sweet almond oil, 300g of coconut oil, 300g of linseed oil) mixed oil, add 20g of oleic acid and mix to obtain an oil phase; add the oil phase into a high-shear emulsifier at a uniform speed to prepare a fat emulsion solution , add water for injection to 10000ml, until a stable fat emulsion submicroemulsion solution is formed, filter through a microporous membrane, subpackage, and spin sterilize, as the test drug solution of Example 2, the content of CBD is 0.02559mg / ml, THC Content of 0.00428mg / ml, CBN content of 0.00856mg / ml (ratio about 6:1:2); according to this method to prepare other examples and comparative examples for testing liquid.

[011...

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Abstract

The invention discloses a composition with sedative and sleep-aiding effects and an application thereof. The composition comprises the following active components in parts by weight: 4-8 parts of cannabidiol, 0.5-1.5 parts of tetrahydrocannabinol and 1.3-2.7 parts of cannabinol. In the composition provided by the invention, different cannabis sativa extracts are combined in proportion, the effects of calming, sleep aiding and the like are achieved through the interaction of the medicinal components, and the composition is particularly suitable for various crowds with high pressure at present.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composition with sedative and sleep-promoting effects and its use. Background technique [0002] At present, with the acceleration of the pace of life, the increase of life pressure, the number of people living alone is increasing, and the people with sleep disorders, anxiety and depression are developing from middle-aged and elderly people to younger people. People are also paying more and more attention to the impact of sub-health status on quality of life. Depressed and depressed people are the main force in sub-healthy people. [0003] Insomnia is mainly manifested as difficulty in falling asleep, difficulty in maintaining sleep time or easy awakening. The cause may be physical disease, mental stress or disease, environmental reasons, etc. Currently, the drugs used to improve sleep in the drug market mainly have effects on the central nervous system. Sedative and hypnotic barbitura...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K31/352A61K31/05A61P25/20A61K8/49A61K8/34A61Q19/00A23L33/105A23L33/115
CPCA61K31/05A61K31/353A61K31/352A61P25/20A61K8/498A61K8/347A61Q19/00A23L33/105A23L33/115A23V2002/00
Inventor 邹陈东肖挽李国辉黄穗
Owner HEMPIRE (SHANGHAI) PHARM R&D LTD