Application of nitric oxide spin trapping type nano targeting antioxidant in preparation of diabetes prevention medicine

A diabetes drug and antioxidant technology, applied in the field of medicine, can solve the problems of unsatisfactory clinical application effect and the like, and achieve the effects of inhibiting the increase of gluconeogenesis, inhibiting the increase of glucose tolerance, and having good application prospects.

Pending Publication Date: 2021-06-22
FUDAN UNIV
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  • Abstract
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Problems solved by technology

At present, some antioxidants have been reported to have good application prospects in animal models of diabetes, but the clinical application effect is not very satisfactory

Method used

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  • Application of nitric oxide spin trapping type nano targeting antioxidant in preparation of diabetes prevention medicine
  • Application of nitric oxide spin trapping type nano targeting antioxidant in preparation of diabetes prevention medicine
  • Application of nitric oxide spin trapping type nano targeting antioxidant in preparation of diabetes prevention medicine

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Embodiment Construction

[0023] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0024] Experimental Materials

[0025] Blood glucose meters were purchased from Roche, Switzerland; Grx2, Trx2 and Prx3 antibodies were purchased from Protein Technology Company (China); p-PGC-1α, PGC-1α and Nrf1 antibodies were purchased from Cell Signaling Technology Company (USA).

[0026] Diabetic mouse model establishment

[0027] KM male mice (body weight 25–30 g) were purchased from Jessie Animals (Shanghai, China). Mice were divided into 4 groups: control (Ctl), diabetic (Db), diabetic + control intervention (Db + V) and diabetic + nano-antioxidant intervention (Db + NM), 8-10 mice in each group. The diabetic group fasted for 12 hours, intraperitoneally injected 0.1 M streptozotocin citrate (STZ) solution (pH 4.5) on the first day, the dose was 80 mg / kg, and injected intraperitoneal...

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Abstract

The invention belongs to the technical field of medicine and pharmacology, and particularly relates to an application of a nitric oxide spin trapping type nano targeting antioxidant capable of targeting liver mitochondria in preparation of a medicine for preventing diabetes mellitus. The nano targeting antioxidant provided by the invention can obviously inhibit the increase of glucose tolerance of diabetic mice, inhibit the increase of gluconeogenesis ability of the diabetic mice, and prevent the occurrence and development of diabetes mellitus by up-regulating expression of liver antioxidant protein, increasing mitochondrial generation of mice liver and improving mitochondrial energy metabolism function. Therefore, the nano antioxidant can be used for preparing medicines or health-care products for preventing diabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of a nitrogen oxide spin-trapping nano-targeted antioxidant capable of targeting liver mitochondria in the preparation of diabetes prevention drugs. Background technique [0002] Type 2 diabetes (T2DM) is a global disease burden and is considered to be one of the major challenges to human health in the 21st century, seriously threatening human health and life. In 2017, the 8th edition of the global diabetes distribution data released by the International Diabetes Federation (IDF) showed that there are currently 425 million adults (20-79 years old) suffering from diabetes worldwide, with a prevalence rate of about 8.8%. Diabetes is the leading cause of vision loss, amputation, and end-stage renal disease, and is also an important risk factor for atherosclerosis, which in turn induces the occurrence of cardiovascular disease and ultimately leads to deat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/66A61K31/15A61P3/10A23L33/10
CPCA61K31/66A61K31/15A61P3/10A23L33/10A23V2002/00A23V2200/328
Inventor 施冬云吴美玲刘珊林
Owner FUDAN UNIV
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