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Application of colla corii asini bone-strengthening oral liquid in preventing and/or treating anemia

A technology of Qianggu oral liquid and donkey-hide gelatin, which is applied in the field of medicine, can solve the problems of high price and achieve the effects of promoting the body's oxygen supply, increasing hemoglobin, improving blood picture and iron metabolism

Pending Publication Date: 2022-06-17
新疆华世丹药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, some hematopoietic growth factors are used as drugs for tumor anemia, such as granulocyte-macrophage colony-stimulating factor (GM-GSF), erythropoietin (EPO), thrombopoietin (TPO), etc., but the price is expensive

Method used

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  • Application of colla corii asini bone-strengthening oral liquid in preventing and/or treating anemia
  • Application of colla corii asini bone-strengthening oral liquid in preventing and/or treating anemia
  • Application of colla corii asini bone-strengthening oral liquid in preventing and/or treating anemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Ejiao Qianggu Oral Liquid improves iron deficiency anemia.

[0029] 1 material

[0030] 1.1 Drugs

[0031]The donkey-hide gelatin oral liquid used in this study was provided by Xinjiang Huashidan Pharmaceutical Co., Ltd. It is a modern oral liquid preparation made from rehmannia glutinosa, donkey-hide gelatin, wolfberry, oyster, astragalus, and Codonopsis pilosula (batch number: 2019111802); Ferrous succinate (batch number: 180319 190410 190610); compound donkey-hide gelatin paste (batch number: 1806027 1904070); low-iron feed (Ruidi Biotechnology Shenzhen Co., Ltd., batch number: 18073112, iron content 6.7mg / kg).

[0032] 1.2 Experimental animals

[0033] Healthy male SD rats (90 SPF grades, purchased from the Experimental Animal Research Center of Xinjiang Medical University, experimental animal production license number: SCXK (new) 2018-0002, experimental animal breeding environment: temperature 24 ~ 26 ℃, humidity 60% ~70%, lighting at intervals of 12h / ...

Embodiment 2

[0080] Example 2 Ejiao Qianggu Oral Liquid improves renal anemia.

[0081] 1. Materials

[0082] 1.1 Animals

[0083] Clean grade SD rats, weighing about 180-200g, male and female, 100 rats. Provided by the Animal Experiment Center of Xinjiang Medical University, license number: SCXK (new) 2018-0001.

[0084] 1.2 Reagents

[0085] Adenine (Jiangxi Alpha Gaoke Pharmaceutical Co., Ltd., 20200501, 1kg / bag);

[0086] Recombinant human erythropoietin EPO injection (Baxter Oncology GmbH, 9J341A, specification 10,000 U / bottle);

[0087] Ejiao Qianggu Oral Liquid (Huashidan Pharmaceutical Co., Ltd., 19021201, specification 10ml / bottle);

[0088] Mouse SOD ELISA Kit, Cat. No. JL22893, Shanghai Future Industrial Co., Ltd.;

[0089] Mouse GST ELISA Kit, Cat. No. JL11340, Shanghai Future Industrial Co., Ltd.;

[0090] Mouse EPO enzyme-linked immunosorbent assay kit, Cat. No. JL11719, Shanghai Future Industrial Co., Ltd.

[0091] 1.3 Instruments

[0092] Disposable syringe, gavage...

Embodiment 3

[0161] Example 3 Ejiao Qianggu Oral Liquid improves myelosuppressive anemia.

[0162] 1. Materials

[0163] 1.1 Animals

[0164] BALB / c mice, weighing about 18-20g, male and female, 100. Provided by the Animal Experiment Center of Xinjiang Medical University, license number: SCXK (new) 2018-0001.

[0165] 1.2 Reagents

[0166] Chloramphenicol Tablets (Chongqing Dikang Changjiang Pharmaceutical Co., Ltd., 200202, 0.25g / tablet)

[0167] Cyclophosphamide for injection (Baxter Oncology GmbH, 9J341A, specification 0.25g / bottle)

[0168] Recombinant human colony-stimulating factor injection (Shuanglu Pharmaceutical, 20191010, specification 150ug / bottle)

[0169] Ejiao Qianggu Oral Liquid (Huashidan Pharmaceutical Co., Ltd., 19021201, specification 10ml / bottle)

[0170]Compound donkey-hide gelatin paste group (Dong'e donkey-hide gelatin, 1905026, 10mL / bottle)

[0171] Mouse Interleukin 6 ELISA Kit, Cat. No. JL20268, Shanghai Future Industrial Co., Ltd.;

[0172] Mouse Macroph...

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Abstract

The invention discloses application of colla corii asini bone-strengthening oral liquid to prevention and / or treatment of anemia, and belongs to the technical field of medicines, and the anemia comprises iron-deficiency anemia, renal anemia and myelosuppression anemia. The colla corii asini bone strengthening oral liquid can increase erythrocyte count, hemoglobin concentration, hematocrit, erythrocyte average hemoglobin amount, erythrocyte average hemoglobin concentration and / or erythrocyte average volume; the serum iron content is increased; a transporter divalent metal transporter and a membrane iron transporter are increased; the intestinal iron absorption is promoted. The composition specifically comprises urea nitrogen and creatinine; related indexes of renal anemia are improved; the immune index of renal anemia can be improved. The percentage of leukocytes and lymphocytes of anemia caused by myelosuppression can be recovered; the hemoglobin content is increased; the number of macrophage colony stimulating factors and / or bone marrow cells in serum is increased; the immunocompetence is improved; the proliferation of lymphoid B cells and macrophages is promoted.

Description

technical field [0001] The Ejiao Qianggu Oral Liquid prevents and / or treats anemia, and the anemia includes iron-deficiency anemia, renal anemia, and myelosuppressive anemia, and belongs to the technical field of medicine. Background technique [0002] Anemia refers to a common clinical symptom in which the volume of red blood cells in the peripheral blood of the human body is reduced, which is lower than the lower limit of the normal range. It can be complicated by many diseases. standard. According to WHO statistics, about 2 billion people suffer from different degrees of iron deficiency or iron deficiency anemia, accounting for about 30% of the world's population. It is one of the four major nutritional deficiency diseases in the world. The annual incidence of anemia in infants and children in my country 45.7%, and the incidence rate of anemia in the elderly over 65 years old is 52%, so the prevention and treatment of anemia is urgent. [0003] According to the clinical ...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P7/06A61P37/04A61P13/12A61K35/36A61K35/618
CPCA61K36/804A61K35/36A61K36/815A61K35/618A61K36/481A61K36/344A61P7/06A61P37/04A61P13/12A61K2300/00
Inventor 武嘉林马芹许兆辉范文玺黄卉陈伟邹伟建刘利恰木斯亚·吐尔逊哈里
Owner 新疆华世丹药业股份有限公司
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