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Diarylnonane Ⅱ and Ⅰ free radical inhibitors in Saxifrage tangutica and its separation, preparation and application

A technology of diaryl nonane and tangut saxifera, which is applied in the field of separation of diaryl nonane free radical inhibitors, can solve problems not involving diaryl nonane free radical inhibitors, and achieve low-cost separation The effect of average cost, low cost, and easy batch material preparation

Active Publication Date: 2022-04-05
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Our research group has applied for a national invention patent (application number: 202010041021.3) to describe the separation, preparation and application of six galloyl-based natural free radical scavengers with known structures in Saxifrage tangutica, and up to now There are no literature or patent reports involving diarylnonane free radical inhibitors

Method used

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  • Diarylnonane Ⅱ and Ⅰ free radical inhibitors in Saxifrage tangutica and its separation, preparation and application
  • Diarylnonane Ⅱ and Ⅰ free radical inhibitors in Saxifrage tangutica and its separation, preparation and application
  • Diarylnonane Ⅱ and Ⅰ free radical inhibitors in Saxifrage tangutica and its separation, preparation and application

Examples

Experimental program
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Effect test

Embodiment 1

[0063] The separation and preparation process of diarylnonane class II and I free radical inhibitors in saxifrage tangutata specifically includes the following steps:

[0064] Step 1, extraction: dry 500g of saxifrage whole herb in the shade, coarsely crush it and extract it with methanol at a material-to-liquid ratio of 1g: 5mL, extract 4 times at room temperature for 2 hours each time, filter and combine the filtrates, namely filtrate A, The filtrate A is mixed according to the amount of polyamide: the amount of saxifrage tangutica medicinal material = 1:5 and then dried under reduced pressure. The conditions for drying under reduced pressure are: vacuum degree 50mbar, temperature 40°C, to obtain saxifrage tangutatus Grass extract mixed sample 160.2g;

[0065] Step 2, coarse separation of microporous resin column: sample mixed with saxifrage extract of Tangutia tanguticae, the sample is separated by medium-pressure chromatography equipped with microporous resin, detected by ...

Embodiment 2

[0073] The separation and preparation process of diarylnonane class II and I free radical inhibitors in saxifrage tangutata specifically includes the following steps:

[0074] Step 1, extraction: dry 1000g of saxifrage whole herb in the shade, coarsely crush it and extract it according to the ratio of solid to liquid: 1g: 100mL of methanol, extract twice at room temperature, each time for 4h, filter and combine the filtrates, that is, filtrate A, The filtrate A is mixed according to the amount of polyamide: the amount of saxifrage tangutica medicinal material = 1:5 and then dried under reduced pressure, wherein the conditions for drying under reduced pressure are: vacuum degree 250mbar, temperature 60°C, to obtain saxifrage tangutatus Grass extract mixed sample 319.3g;

[0075] Step 2, coarse separation of microporous resin column: sample mixed with saxifrage extract of Tangutia tanguticae, the sample is separated by medium-pressure chromatography equipped with microporous res...

Embodiment 3

[0083] The separation and preparation process of diarylnonane class II and I free radical inhibitors in saxifrage tangutata specifically includes the following steps:

[0084] Step 1, extraction: dry 1200g of saxifrage whole herb in the shade, coarsely crush it and extract it according to the ratio of solid to liquid: 1g: 50mL of methanol, extract at room temperature 3 times, each time for 3h, filter and combine the filtrates, that is, filtrate A, The filtrate A is mixed according to the amount of polyamide: the amount of saxifrage tangutica medicinal material = 1:5 and then dried under reduced pressure, wherein the conditions for drying under reduced pressure are: vacuum degree 150mbar, temperature 50°C, to obtain saxifrage tangutatus Grass extract mixed sample 363.7g;

[0085] Step 2, coarse separation of microporous resin column: sample mixed with saxifrage extract of Tangutia tanguticae, the sample is separated by medium-pressure chromatography equipped with microporous re...

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Abstract

The invention discloses a diaryl nonane class II and I free radical inhibitor in saxifrage tanguta and its separation preparation process and application. The specific process is: extraction, microporous resin column rough separation, on-line free radical inhibitor component screening, reversed-phase medium-pressure chromatographic column separation, on-line free radical inhibitor screening and high-pressure preparative column preparation and other steps. The prepared free radical inhibitor can be used in the preparation of free radical inhibiting drugs or health food, specifically, as an active ingredient, it can be made into various pharmaceutical preparations or health food according to any carrier acceptable in pharmacy or food science. Extraction solvents, microporous resin columns, solvents and separation materials used in the separation of reversed-phase medium-pressure chromatographic columns in the process can all be recycled; raw materials come from a wide range of sources, such as methanol room temperature cold immersion extraction, microporous resin column rough separation and reversed-phase medium Large-scale operation can be realized in the process steps such as pressure chromatographic column separation, and high-pressure preparative chromatographic separation can ensure the purity of the product to be greater than 95%.

Description

technical field [0001] The invention relates to the technical field of separation of diarylnonane free radical inhibitors in Saxifraga tangutica, in particular to the separation and preparation process of diarylnonane class II and I free radical inhibitors in Saxifraga tangutica and its separation and preparation process. application. Background technique [0002] Saxifraga tangutica Engl., also known as Ganqing saxifrage, is an annual evergreen herb of Saxifragaceae (Saxifragaceae) genus Saxifraga. Tibetan medicine name: "Songjidi", traditional Chinese medicine It is called "Dieda" in Chinese, and it is mainly distributed in Qinghai, Gansu, Tibet, Sichuan, and Bhutan and Kashmir under the coniferous forest shrubs at an altitude of 2900-4900 meters. Tangut saxifrage is a commonly used Tibetan medicine, and the whole herb can be used as medicine. "Chinese Medicine Cihai" records: its nature and taste are slightly bitter, pungent, and cold. Main effects: clearing the liver a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/18C07H15/24C07H1/08A61P39/06A23L33/105
CPCC07H15/18C07H15/24C07H1/08A61P39/06A23L33/105A23V2002/00A23V2200/30A23V2250/2132
Inventor 党军王启兰陶燕铎
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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