Preparation method of nanoscale 3-aminophenol formaldehyde resin particles based on microfluidic technology

A microfluidic technology and formaldehyde resin technology, which is applied in the field of preparation of nano-scale 3-aminophenol formaldehyde resin particles, can solve the problems of rough process parameter control, low-efficiency heat and mass transfer, and achieve the promotion of heat and mass transfer , the effect of small polydispersity index and small size

CN113072670BActive Publication Date: 2022-02-01XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2022-02-01

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Abstract

The invention discloses a preparation method of nano-scale 3-aminophenol formaldehyde resin particles based on microfluidic technology. The preparation method combines a droplet generating chip and a microreactor combined with a spiral pipeline. Inject 3-aminophenol, formaldehyde, and ammonia water into the channel of the chip respectively and combine them as the dispersed phase, and simethicone as the continuous phase. Under the action of shearing, a liquid droplet or liquid column containing the reaction raw materials is formed, and after passing through a spiral pipe heated by a water bath Final aggregation is done. Adjusting the flow rate, temperature and reaction time can adjust the size and dispersibility of the particles; the invention is a simple synthesis method capable of preparing 3-aminophenol formaldehyde resin beads with good dispersibility and small size. The process is fast, safe, and easy to operate. The prepared 3-aminophenol formaldehyde resin has small size and good dispersion, and the preparation effect is better than traditional industrial preparation. It has very important value in the field of micro-nano material preparation.
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Description

technical field

[0001] The invention belongs to the field of nanomaterial preparation based on microfluidic technology, and in particular relates to a method for preparing nanoscale 3-aminophenol formaldehyde resin particles based on microfluidic technology. Background technique

[0002] Among various phenolic resins, 3-aminophenol-formaldehyde resin has a stable three-dimensional structure and is widely used to prepare the matrix of functional materials. Good application prospects (Xiao Q. et al. Mater. Chem. Phys. 2020, 239; Du, J. et al. Carbon, 2020, 156, 523-528; Tian, ​​J. et al. Colloid. Surface. A, 2019 ,568,195-203), especially the nanoscale resin spheres show good biocompatibility in biomedical applications, and can be further applied to cell delivery vehicles, cell targeting, and imaging (Fang, Y.et al.Angew.Chem., Int.Ed.2010,49,7987-7991; Motawie,A.M.; Sadek,E.M.Polym.Adv.Technol.1998,9,837-843; 2020, 401, 126063). With the increasing application of phenolic ...

Examples

Embodiment 1

[0027] 1) Preparation of microreactor: The PDMS chip is prepared by soft lithography technology. The cross-section of the chip channel is uniformly square, with a side length of 600 μm; the included angle of the raw material adding channel is 45°; the meandering channel has an outer diameter of 2.1 mm and an inner diameter of 1.5 semi-circular channels, the total length is 35mm; the heating pipe is made of PTFE tube, the inner diameter of the tube is 0.6mm, the length of the tube is 15.9m, and the length of the part of the tube wound on the glass rod with an outer diameter of 10mm is 15.1m; one end of the spiral structure PTFE tube and the chip Outlet connection, one end inserted into the Erlenmeyer flask;

[0028] 2) Take 0.35g of 3-aminophenol, 0.75g of formaldehyde, and 0.52g of ammonia water and dissolve them in 10mL of water respectively. After fully dissolving, inhale into a 10mL syringe, and fix the syringe on the digital control micro pump; s Simethicone, inhale into a...

Embodiment 2

[0033] 1) Preparation of microreactor: The PDMS chip is prepared by soft lithography technology. The cross-section of the chip channel is uniformly square, with a side length of 600 μm; the included angle of the raw material adding channel is 45°; the meandering channel has an outer diameter of 2.1 mm and an inner diameter of 1.5 semi-circular channels, the total length is 35mm; the heating pipe is made of PTFE tube, the inner diameter of the tube is 0.6mm, the length of the tube is 15.9m, and the length of the part of the tube wound on the glass rod with an outer diameter of 10mm is 15.1m; one end of the spiral structure PTFE tube and the chip Outlet connection, one end inserted into the Erlenmeyer flask;

[0034] 2) Take 0.35g of 3-aminophenol, 0.75g of formaldehyde, and 0.52g of ammonia water and dissolve them in 10mL of water respectively. After fully dissolving, inhale into a 10mL syringe, and fix the syringe on the digital control micro pump; sSimethicone oil, add 0.01wt...

Embodiment 3

[0039] 1) Preparation of microreactor: The PDMS chip is prepared by soft lithography technology. The cross-section of the chip channel is uniformly square, with a side length of 600 μm; the included angle of the raw material adding channel is 45°; the meandering channel has an outer diameter of 2.1 mm and an inner diameter of 1.5 semi-circular channels, the total length is 35mm; the heating pipe is made of PTFE tube, the inner diameter of the tube is 0.6mm, the length of the tube is 15.9m, and the length of the part of the tube wound on the glass rod with an outer diameter of 10mm is 15.1m; one end of the spiral structure PTFE tube and the chip Outlet connection, one end inserted into the Erlenmeyer flask;

[0040] 2) Take 0.35g of 3-aminophenol, 0.75g of formaldehyde, and 0.52g of ammonia water and dissolve them in 10mL of water respectively. After fully dissolving, inhale into a 10mL syringe, and fix the syringe on the digital control micro pump; sSimethicone oil, add 0.05wt...