Detection method for exciting biological single-molecule terahertz resonance
A detection method, terahertz technology, applied in the direction of measuring devices, analytical materials, laser devices, etc., can solve the problems of limited spectral data readout speed and difficult realization
Pending Publication Date: 2021-07-06
ZHONGBEI UNIV
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Problems solved by technology
However, the time resolution of plasmon-enhanced spectroscopy depends not only on the signal capability enhanced by nanoparticle probes, but also limited by the readout speed of the spectrometer.
Moreover, in the detection process, it is necessary to obtain multidimensional data of molecular structure, spatial distribution and dynamic process containing complex information from the sample at the same time, but as far as the current technology is concerned, it is difficult to achieve
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[0022] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0023] Such as Figure 1-4 As shown, the present invention provides a detection method for stimulating biological single molecule terahertz resonance, including a nano-plasmonic optical tweezers device 1, the nano-plasmonic optical tweezers device 1 includes an excitation light unit 2, a surface plasmon The element excitation unit 3 and the monitoring unit 4; the surface plasmon excitation unit 3 includes a glass slide 31 coated with a gold film 30, the surface of the glass slide 31 is provided with a micro-nano structure solution, and the micro-nano structure solution is used for dynamic manipulation and trap biological single molecules to be detected;
[0024] The excitation light unit 2 generates terahertz light, and injects the terahertz light into the surface plasmon excitation unit 3. The terahertz light excites biological single-molec...
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The invention discloses a detection method for exciting biological single molecule terahertz resonance, the detection method comprises a nano plasmon optical tweezers device, and the nano plasmon optical tweezers device comprises an excitation light unit, a surface plasmon excitation unit and a monitoring unit. The surface plasmon excitation unit comprises a slide plated with a gold film, a micro-nano structure solution is arranged on the surface of the slide, and the micro-nano structure solution is used for dynamically controlling and trapping biological single molecules to be detected; the excitation light unit generates terahertz light and emits the terahertz light to the surface plasmon excitation unit, the terahertz light excites biological single-molecule terahertz resonance, the terahertz light is coupled with reflected light of the micro-nano structure solution on the slide, and coupled light obtained after coupling is reflected into the monitoring unit, and high-resolution optical characterization of the biological single-molecule vibration spectrum is obtained. According to the scheme, optical direct measurement is carried out on vibration of the single biological single molecule in the solution, and the terahertz vibration spectrum of the biological single molecule is obtained.
Description
technical field [0001] The invention relates to the technical field of biological single molecule detection, in particular to a detection method for exciting biological single molecule terahertz resonance. Background technique [0002] Biomolecules are important components of living organisms. They not only have biological functions, but also have relatively large molecular weights and complex structures. The complex structure of these biomolecules determines their special properties. Their movements and changes in the body reflect important life functions, such as metabolism, supply of energy and substances needed to maintain life, transmission of genetic information, control of embryonic differentiation, and promotion of growth. development, immune function, etc. The detection and analysis of the structural properties and intermolecular interactions of biomolecules will help people understand the laws of life activities more deeply. [0003] With the development of scien...
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Login to View More IPC IPC(8): G01N21/552H01S3/23
CPCG01N21/554H01S3/23
Inventor 王艳红武京治冀宝庆李孟委
Owner ZHONGBEI UNIV