A surface-enhanced Raman sensing substrate based on Fano resonance and its preparation method
A surface-enhanced Raman and Fano resonance technology, applied in the optical field, can solve the problems of complex preparation, high cost, difficult application, etc., and achieve the effects of simple preparation, uniform distribution, and easy application.
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Embodiment 1
[0042] This embodiment provides a nanosphere-polyethylene glycol-gold film structure surface-enhanced Raman sensing substrate based on Fano resonance, the structure of which is as follows figure 1As shown, the surface-enhanced Raman sensing substrate is prepared on a silicon substrate, and specifically includes: a gold film and nanospheres, wherein the nanospheres are silica nanospheres modified with Avidin (avidin); The surface of the gold film is chemically modified with Biotin-PEG-SH (thiol-polyethylene glycol-biotin) chemical reagent, and the thiol (SH) is strongly chemically linked to the gold film, and PEG (polyethylene glycol) Used to control the length by different molecular weight, Biotin (biotin) and Avidin (avidin) for strong chemical linkage, such as figure 2 and, the surface of the silica nanospheres is covered with a gold-plated layer.
[0043] In this embodiment, in the surface-enhanced Raman sensing substrate structure, the thickness of the gold film is 290nm...
Embodiment 2
[0067] This embodiment provides a nanosphere-polyethylene glycol-gold film structure surface-enhanced Raman sensing substrate based on Fano resonance, the structure of which is as follows figure 1 As shown in the figure, the surface-enhanced Raman sensing substrate is prepared on a silicon substrate, and specifically includes: a gold film and nanospheres, wherein the nanospheres are gold nanospheres, and SH-Avidin (thiol-avidin) is used for the nanospheres. Carry out chemical modification, so that the surface is modified with Avidin (avidin); the surface of the gold film is chemically modified with Biotin-PEG-SH (thiol-polyethylene glycol-biotin) chemical reagent, and the thiol (SH) and the The gold film is strongly chemically linked, PEG (polyethylene glycol) is used to control the length through different molecular weights, and Biotin (biotin) and Avidin (avidin) are strongly chemically linked, such as figure 2 shown.
[0068] Compared with Example 1, the difference betwee...
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