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Bioartificial liver support system based on placenta mesenchymal stem cell bioreactor

A technology of bioreactor and liver support system, applied in the field of bioartificial liver support system, can solve the problems of difficulty in extracting exosomes from mesenchymal stem cells, difficulty in clinical application transformation, and small number of culture expansions, so as to reduce biological safety. The effect of risk, short time-consuming and low technical difficulty

Inactive Publication Date: 2021-07-09
GUANGDONG UNISUN BIOTECHNOLOGY CO LTD
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Problems solved by technology

[0003] In recent years, mesenchymal stem cells have been more and more used in organ transplantation for liver function restoration, immunosuppression, etc., but at present, the number of mesenchymal stem cell culture and expansion is small, and the extraction of mesenchymal stem cell exosomes is difficult and costly. high
At present, the experiments are mainly aimed at small experimental animals, and it is difficult to transform them into clinical applications.
At present, there is no clinical method to effectively apply mesenchymal stem cells in the treatment of clinical liver failure

Method used

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  • Bioartificial liver support system based on placenta mesenchymal stem cell bioreactor

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Embodiment Construction

[0019] The embodiments of the present application are described in detail below, and examples of the embodiments are illustrated in the drawings, wherein the same or similar reference numerals are indicated by the same or similar elements or elements having the same or similar functions. The following is exemplary, and is intended to explain the present application by referring to the embodiments described with reference to the accompanying drawings.

[0020] See figure 1 The present application relates to a biological artificial liver support system based on placenta-mesenchymal stem cell bioreactor, which is used in the treatment of clinical liver failure. It solves how to effectively use mesenchymal stem cells into artificial liver systems. The problem, thus constructing a new biological artificial liver system to treat liver failure, providing new treatment strategies for patients with liver failure.

[0021] The biological artificial liver support system based on the placenta...

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Abstract

The invention provides a bioartificial liver support system based on a placenta mesenchymal stem cell bioreactor, which comprises an artery pipeline, a vein pipeline, a plasma separator, a plasma separation pipeline, a bioreactor and a plasma return pipeline, and is characterized in that the plasma separator comprises a blood inlet, a plasma outlet and a blood cell outlet; the artery pipeline is provided with a blood pump and is connected with the blood inlet, the vein pipeline is connected with the blood cell outlet, the plasma separation pipeline is provided with a circulating pump, two ends of the circulating pump are respectively connected with the plasma outlet and the bioreactor, the bioreactor is inoculated with placenta mesenchymal stem cells, and the plasma return pipeline is connected with the bioreactor and the vein pipeline. By arranging the bioreactor inoculated with the placenta mesenchymal stem cells, the mesenchymal stem cells can be prevented from entering receptor plasma, small molecules such as exosomes of the mesenchymal stem cells can be freely exchanged between the receptor plasma and the mesenchymal stem cells, and then the mesenchymal stem cells can be effectively applied to clinical hepatic failure treatment.

Description

Technical field [0001] The present application relates to the technical field of medical devices, and in particular, there is a biological artificial liver support system based on placental mesenchymal stem cell bioreactor. Background technique [0002] Artificial liver support system as a new method for treating liver failure is a hot spot for research. Artificial liver support system mainly includes non-biological artificial liver, biometric artificial liver and combined biological artificial liver support system, a large number of studies show that non-biological artificial liver support system does not significantly improve the survival rate, biological artificial liver and combination of patients with liver failure Type biological artificial liver support system is a hot spot for research. However, due to the limitations of various biological artificial liver seed cells and the limited limitation of biomechanics after amplification, there is no ideal biological artificial li...

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Application Information

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IPC IPC(8): A61M1/36A61M1/38
CPCA61M1/3621A61M1/38
Inventor 高毅王毅冯磊何国林易笑
Owner GUANGDONG UNISUN BIOTECHNOLOGY CO LTD
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