Device for delivering pulsed electric field ablation energy to endocardium tissue

Abstract

The invention relates to a device for delivering pulsed electric field ablation energy to an endocardium tissue, and belongs to the technical field of medical instruments. The device for delivering the pulsed electric field ablation energy to the endocardium tissue comprises an ablation device, a handle, a pulsed electric field generator and a control system; the ablation device is connected with the pulsed electric field generator and the control system through the handle; the ablation device is provided with a plurality of positive and negative electrodes which are alternatively arranged; and the ablation device is of a multi-layer spiral conical structure which is in contact with the endocardium tissue and can be movably folded and unfolded. Compared with the prior art, the device for delivering pulsed electric field ablation energy to the endocardium tissue has the effects that different parts can be ablated at the same time, the electric field ablation range is larger, and the ablation effect is more thorough, meanwhile has the advantages that manual operation actions of a doctor can be greatly reduced, and the exposure time under the radiation environment is shortened; reduce the complexity and the error rate of an operation; and has a good clinical effect.

Description

technical field [0001] The invention relates to a device for delivering pulsed electric field ablation energy to endocardial tissue, belonging to the technical field of medical devices. Background technique [0002] Over the past two decades, pulsed electric fields for tissue therapy have migrated from the laboratory to clinical applications, where the application of brief high-voltage DC voltages to tissue can generate localized high electric fields, typically in the range of hundreds of volts per centimeter, locally High electric fields disrupt cell membranes by creating pores in them. While the precise mechanism for the generation of this electrically driven pore, or electroporation, continues to be investigated, it is believed that the application of a relatively brief and large electric field generates instability in the lipid bilayer in the cell membrane, resulting in localized Distribution of gaps or pores. This electroporation may be irreversible when the applied e...

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Problems solved by technology

However, the operation of this structure is cumbersome, and the doctor needs to constantly adjust the unfolded shape of the electrode, and it is necessary to stop and maintain the structure of the electrode unfolded shape, which makes the structure complex, and there is a risk of structural failure leading to ablation failure

[0004] Chinese Patent No. CN201680046257 discloses an electrode structure for irreversible electroporation ablation. In this structure, the electrodes are arranged in a ring-shaped structure. The structure is simple and the operation is more convenient. However, the electrode of this structure has a single diameter and cannot simultaneously ablate the pulmonary vein ostium and internal

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