Application of micromolecule non-encoding RNA and host gene in diagnosis and treatment of gastric cancer

A non-coding, small molecule technology, applied in the field of oncology, can solve the problem of less research on targeted therapy for gastric cancer
CN113151280APending Publication Date: 2021-07-23JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2021-07-23

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Abstract

The invention discloses a micromolecule non-encoding RNA (microRNA-210), a host gene (lncRNA MIR210HG) of the micromolecule non-coding RNA (microRNA-210) and application thereof. The microRNA-210 and the lncRNA MIR210HG disclosed by the invention can be used as specific markers of the gastric cancer. Besides, an in-vitro metastasis chamber and an in-vivo mouse tail intravenous injection tumor cell lung metastasis model are carried out, which shows that the microRNA-210 and the lncRNA MIR210HG can promote gastric cancer cell metastasis, and the gastric cancer cell metastasis can be inhibited by inhibiting a common transcription factor of the microRNA-210 and the lncRNA MIR210HG. Therefore, the microRNA-210, the lncRNA MIR210HG and the common transcription factor of the microRNA-210 and the lncRNA MIR210HG can be used for gastric cancer diagnosis, can also be used as targets for preparing drugs for inhibiting gastric cancer metastasis or anti-tumors, and can provide a new thought and a new way for gastric cancer treatment.
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Description

technical field

[0001] The present invention relates to a small molecule non-coding RNA (microRNA-210) and its host gene (lncRNAMIR210HG), in particular to the application of the small molecule non-coding RNA (microRNA-210) and its host gene (lncRNA MIR210HG) in the diagnosis and treatment of gastric cancer. in the field of oncology. Background technique

[0002] Gastric cancer (Gastric Cancer) is the fourth most common cancer in the world, ranking fourth among men and fifth among women worldwide. Although the incidence of gastric cancer has decreased in some countries, due to its high lethality, gastric cancer ranks second in the world in cancer-related deaths. my country is a country with a high incidence of gastric cancer. The latest statistics show that in China, the incidence of gastric cancer is as high as 679.1 per 100,000 people, and the death rate is as high as 498.0 per 100,000 people. In recent years, thanks to the popularization of gastrointestinal endoscopy an...

Claims

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