Cosmetic for repairing and relieving skin irritation and preparation method thereof

A technology for skin irritation and cosmetics, applied in cosmetic preparations, cosmetics, preparations for skin care, etc., can solve problems such as skin barrier dysfunction repair, and achieve the effect of restoring skin barrier function, excellent skin beautifying effect, and relieving skin irritation.

Active Publication Date: 2021-07-27
COSMAX CHINA INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the defect that the existing technology cannot fundamentally solve the problem of repairing skin barrier dysfunction, the present invention uses the combination of Monascus fermented product extract and comfrey

Method used

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  • Cosmetic for repairing and relieving skin irritation and preparation method thereof
  • Cosmetic for repairing and relieving skin irritation and preparation method thereof
  • Cosmetic for repairing and relieving skin irritation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0048] Example 1: Preparation method of red yeas fermentation product extract

[0049] 1. Fermentation method of red yeas fermentation product:

[0050] (1) Liquid seed culture: Take about 5 g of large curve in a 250 ml triangular bottle, add about 30 ml of sterile water, shake 30 min, form a bacterius suspension, and a bacteria suspension is inoculated in proliferation medium, 30 ° C, 30 ° C, 120 r / min was cultured for 4 days to obtain liquid seed fluid.

[0051] (2) Solid state fermentation: Select a number of glutinous rice, uniform and placed in a 50 ° C constant temperature environment for drying. It is then weighed, poured into a triangular bottle having a volume of 500 ml. Selecting the pure water in the beaker, adding a lactic acid thereto, until the pH of the solution is 5.0, and the solution is poured into the corner bottle, and there is no glutinous rice top 5 cm. Soak 12h gently shake the triangle bottle, and the measuring rice is not white.

[0052] After the glutin...

Example Embodiment

[0059] Example 2: Preparation method of purple grass extract

[0060] Drying Xinjiang loose, pulverized 60 mesh, sterilized, placed in an extraction tank, add palmitate ethylhexylhexide (10 ml / g), and allows for 24 h at room temperature, centrifugal filtration to obtain a purple extract.

Example Embodiment

[0061] Example 3:

[0062] In vitro assays to explore the effects of red-curved extract combined with vapor extract to secrete germocarbamide, free fatty acids, and transmissive acid to evaluate its repair effect on skin barrier function.

[0063] 1, test sample processing

[0064] DMSO dissolves the purple grass extract, then add the red yeas fermentation product extract, and finally add Epilife TM The medium, according to the ratio and specific feed in Tables 1 and 2, different Epilife respectively TM Medium mixed solution. There are 7 groups of different proportions, and the contrast is 3 groups.

[0065] Table 1 Cell test ratio

[0066]

[0067]

[0068] Table 2 Cell Test Composition

[0069]

[0070] 2, cell culture

[0071] Normal human skin HEKA cells with Epilife containing 1% HKGS (human keratin forming cell growth additive) TM Medium (containing PSA liquid: penicillin, streptomycin and amphotericin B), at 37 ° C, 5% C0 2 In the incubator, it is conventionally cultu...

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PUM

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Abstract

The invention discloses a cosmetic for repairing and relieving skin irritation and a preparation method thereof. The composition comprises a monascus fermentation product extract and a lithospermum extract. Cell tests find that the composition has a synergistic effect and can effectively promote skin cells to secrete hyaluronic acid, ceramide and free fatty acid; and after a human body test, the skin of a volunteer is obviously improved, and the skin moisture content and the skin barrier function are well improved.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and relates to a cosmetic for repairing and alleviating skin irritation and a preparation method, in particular to a cosmetic composition comprising a combination of a monascus fermented product extract and a comfrey extract. Background technique [0002] The skin is the largest organ of the human body and plays an important role in human immunity; the skin can be roughly divided into 3 layers, which are subcutaneous tissue, dermis, and epidermis from the inside to the outside; the epidermis can be divided into the basal layer and spinous layer , granular layer, transparent layer, stratum corneum. The stratum corneum is in direct contact with the external environment and provides a physical immune barrier for the skin. The skin barrier is composed of keratin in the stratum corneum of the skin surface, a brick wall structure formed by intercellular lipids, and mucopolysaccharides. Among them, i...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9728A61Q19/00
CPCA61K8/9789A61K8/9728A61Q19/00A61K2800/85
Inventor 朱云周秋娜金炫延金荣熙申彦晟金延埈
Owner COSMAX CHINA INC
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