A kind of preparation device of pregabalin intermediate compound

Abstract

The invention discloses a preparation device for an intermediate compound of pregabalin, comprising a main body and a straight-through tube installed on the main body, wherein a rotating bottle is installed on the main body near the corresponding end of the straight-through tube, and the main body is close to the other end of the straight-through tube The position of the condensing pipe part that can automatically loosen the movable interface and effectively facilitate the real-time dismantling of the rotating bottle is provided. The preparation device of the pregabalin intermediate compound is different from the prior art. During the rotary evaporation process, the interfaces on the movable condenser tube parts are automatically loosened, which can effectively avoid the problem of seizing caused by the long-term tightening of the connecting parts on the condenser tube, so as to effectively maintain the condenser tube parts, and at the same time, it can effectively facilitate the real-time removal of the rotary bottle. , which facilitates the real-time use of rotary evaporator equipment.

Description

technical field [0001] The invention relates to the technical field of preparing pregabalin intermediate compounds, in particular to a preparation device for pregabalin intermediate compounds. Background technique [0002] Pregabalin is a white or almost white crystalline powder chemical. It is an antiepileptic drug and is mainly used in the clinical treatment of postherpetic neuralgia. [0003] During the preparation of the intermediate compound of pregabalin, compound 4 (482 mg, 2 mmol) and 10 mL of methanol need to be added to a 50 mL dry three-necked flask, sodium hydroxide (800 mg, 20 mmol) is added, and reflux extraction is performed 3 times under stirring. , the organic layer was washed twice with saturated brine, dried by adding anhydrous magnesium sulfate, and the solvent was removed with a rotary evaporator, and the intermediate compound was obtained through subsequent operations. [0004] Among them, the rotary evaporator is used as a preparation device for the i...

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Problems solved by technology

[0005] However, at present, the loosening and active maintenance of each interface connector on the condensing tube of the rotary evaporator is mainly done manually one by one, which is time-consuming and labor-intensive, and the hands are prone to fatigue, which will affect the real-time and efficient preparation. processing efficiency, and in the continuous processing and preparation process, it is easy to ignore the loosening and active maintenance of the equipment, which will affect the convenient disassembly and use of the instrument. Therefore, we propose a preparation device for pregabalin intermediate compounds

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