Method for preparing a 2, 3-dihydrofuran derivative

Abstract

The invention discloses a method for preparing a 2, 3-dihydrofuran derivative through a nitrile C (sp3)-H functionalization initiated alkenyl-1, 3-dicarbonyl compound free radical cyclization reaction under a metal-free and alkali-free water phase system. The method comprises the following steps: adding an alkenyl-1, 3-dicarbonyl compound, a nitrile compound, an oxidizing agent and water into a Schlenk reaction flask, and stirring and reacting at a certain temperature in an air atmosphere to obtain the 2, 3-dihydrofuran derivative.

Description

technical field

[0001] The application belongs to the field of organic synthesis, in particular to nitrile C (sp) under a metal-free and alkali-free aqueous phase system 3 A green method for the preparation of 2,3-dihydrofuran derivatives by free radical cyclization of alkenyl-1,3-dicarbonyl compounds initiated by )-H functionalization. Background technique

[0002] In modern synthetic chemistry, since solvents account for more than half of the total materials in the reaction process, the development of environmentally friendly and green reaction media remains an important goal. Organic transformations in aqueous solutions have attracted much attention due to the wide variety of sources, redox stability, non-toxicity, safety, and ease of product separation. Meanwhile, the metal-free strategy provides a good platform for pursuing green and sustainable chemistry, which does not require expensive transition metal catalysts or ligands, and has no metal residues in the final pro...

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