Application of glycoside compound in preparation of medicine for treating acute liver failure

A technology of acute liver failure and compounds, applied in the field of medicine, can solve problems such as high cost of liver transplantation, lack of certain effective drugs, and poor efficacy of drugs

Inactive Publication Date: 2021-08-06
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there has been some progress in diagnosis and treatment, there is still a lack of definitive and effective drugs. The existing drugs such as silymarin are not effective, and the cost of liver transplantation is too high

Method used

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  • Application of glycoside compound in preparation of medicine for treating acute liver failure
  • Application of glycoside compound in preparation of medicine for treating acute liver failure
  • Application of glycoside compound in preparation of medicine for treating acute liver failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Treatment of acute liver failure in Kinsenosid; KD)

[0029] Up to 60 SPF-level male C57 rats, raised from the SPF-level experimental animal center of Tongji Medical College in Huazhong University of Science and Technology, given standard diet and drinking water, and the room temperature is controlled at 23 ± 2 ° C, and it is accommodated after 7 days of feeding. Experiments involved in mice were approved by the Animal Experimental Ethics Committee of Tongji Medical College in Huazhong University of Science and Technology. The mouse group is a blank group (Control Group, Distilled Water), model group (Model Group, Distilled Water), high dose group (KD-400GROUP, 400 mg / kg kd), medium dose group (KD-200GROUP, 200mg / KG KD) and low dose group (KD-100GROUP, 100 mg / kg kd), ten in each group. The weighing mouse weight, continued to gum, a total of 10 days, last intraperitoneal injection (control group injection isometric physiological saline), abdominal injection is amino la...

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Abstract

The invention belongs to the field of medicines, and provides a medicine for treating acute liver failure. The invention discovers that a compound kinsenoside (Kinsenoside(3-(R)-3-beta-D-Glucopyranosyloxybutanolide) can effectively prevent the development of acute liver failure, and in a mouse liver failure model, the compound has the activities of improving liver function and oxidative stress injury, and reducing inflammatory factor secretion and the like; and meanwhile, hepatic cell apoptosis is inhibited by protecting the structural integrity of mitochondria, so that the compound has remarkable liver protection activity and can be used as a medicine for treating the acute liver failure for treating the acute liver failure.

Description

Technical field [0001] The present invention relates to the art of medicine, involving drugs for treating liver diseases, and more particularly to drugs for treating acute liver failure, i.e., a glycoside compound is disclosed in the preparation of the application of acute liver failure drugs. Background technique [0002] Acute Liver Failure, ALF is a relatively rare prognosis, and its clinical features are rapid inhibition and progress, mainly as severe, primary liver damage and obvious sense of consciousness and coagulation function. Obstacles, therefore is of great significance in clinical practice (reference: Jiang Wei, Bai Xuefan. Research progress in acute liver failure [J]. Journal of Clinical Hepatobiliary Diseases). East and weekeeper's focus on the focus of basic liver disease and acute attack value, 2017 "The Practice Guide of Acute (Explosive) Liver Failragement in European Liver Diseases in 2017" "Wilson Disease and Budd-Chiari Comprehensive Patients with acute expr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/16C07H17/04
CPCA61K31/7048A61P1/16C07H17/04
Inventor 张勇慧尹杰
Owner HUAZHONG UNIV OF SCI & TECH
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