Preparation method of color developing oral capsule for detecting laryngopharyngeal reflux disease

Abstract

The invention discloses a preparation method of a color developing oral capsule for detecting laryngopharyngeal reflux disease. The preparation method comprises the following steps: coating a color developing agent with a non-degradable high polymer material to form color developing particles; and filling hollow capsule bodies with the color developing particles to obtain the color developing oral capsules. The color developing oral capsule prepared by the invention is low in cost and suitable for clinical general application, can be used for determining laryngeal reflux happens or not by observing the color change of phlegm spitted by a patient, truly becomes an objective, accurate, simple, cheap and safe mode for detecting the laryngeal reflux, and has great economic value and social significance.

Description

technical field [0001] The invention relates to the field of medicines and medical devices, in particular to a preparation method of a color-developing oral capsule for detecting laryngopharyngeal reflux disease. Background technique [0002] Laryngopharyngeal reflux disease is a series of syndromes caused by the reflux of gastric contents to the larynx, trachea, lungs, pharynx, nasal cavity, oral cavity, middle ear and other parts. sign. Such as chronic pharyngitis, rhinitis, otitis media, laryngitis, bronchitis, asthma, throat tumors and so on. The morbidity rate is very high, with an initial estimate of 5 to 10% of the population. [0003] At present, the clinical diagnosis of laryngopharyngeal reflux is mainly based on subjective speculation of symptom and sign scores and experimental acid treatment, which is difficult to diagnose accurately. Objective detection methods mainly include 24h esophageal pH detection and salivary pepsin detection. Gastric juice contains h...

AI Technical Summary

Problems solved by technology

Esophagus pH detection is the current clinical standard detection method, but it is expensive. A pH value detector is nearly 1 million, and only one person can be detected a day. The method is to insert the detection catheter from the nasal cavity into the throat and esophagus to measure the pH value. It is very painful, and laryngopharyngeal reflux often manifests from time to time. When the patient is tested, there is no reflux, and when there is reflux, he is not checked on the wheel, so the positive rate is low and the clinical practicability is affected; salivary pepsin It costs more than 3,000 yuan to detect one person. At present, the specificity and sensitivity are not high, and there are also cases of no reflux during detection, which is rarely carried out in clinical practice.

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