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Stable stannous oral care product

A technology for oral cavity and high-water oral cavity, applied in the field of preparation and use of the composition, can solve the problems of reduced availability and effectiveness, high manufacturing cost, undesired sensory properties, etc., and achieve the reduction of biofilm and dental plaque , reduce the effect of gingivitis

Pending Publication Date: 2021-08-06
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, low water formulations may have higher manufacturing costs and / or undesired organoleptic properties, while chelating agents may sequester and reduce the availability and availability of beneficial cations such as zinc and stannous ions

Method used

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  • Stable stannous oral care product
  • Stable stannous oral care product
  • Stable stannous oral care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0161] formulation design

[0162] The stability of Sn(II) in aqueous solutions and the ability of various additives to affect this stability was evaluated. figure 1 Shown in zinc phosphate (Zn 3 (PO 4 ) 2 ), TSPP and trisodium citrate alone in the presence of Sn (II) ion stability in 35 days. During this time period, Zn 3 (PO 4 ) 2 The addition of has a positive effect on preventing the oxidation of stannous to tetravalent tin. Without being bound by theory, but given the low solubility of the complex (Zn 3 (PO 4 ) 2 K sp ~10 -35 ), so this is counterintuitive. Given Zn 3 (PO 4 ) 2 It is not generally considered an antioxidant, so these results were all the more surprising.

[0163] figure 2 shows the effect of various composition combinations on the SnF 2 , Zn 3 (PO 4 ) 2 Summary of the effects of slurry and water. Addition of TSPP and citric acid to the Sn and Zn mixture significantly increased the solubility but caused a large impairment of Sn(II) st...

Embodiment 2

[0171] Stannous ion

[0172] Stannous ion stability was assessed over a period of 35 days. image 3 The stability of the stannous ion over a period of 35 days at 60°C is shown. During this time period, the stannous fluoride was significantly oxidized by -80%. In the presence of phosphoric acid, only 8-9% oxidized, suggesting that orthophosphate ions are effective in stabilizing the Sn(II) oxidation state. Addition of phosphoric acid, sodium phosphate, or zinc phosphate to the formulation will provide orthophosphate ions that can be released by dissociation of the parent complex salt:

[0173]

[0174] Polyphosphates do not provide significant oxidation stability compared to orthophosphates. image 3 SnF in the presence of TSPP is also shown 2 . Although the two compounds would coordinate, no oxidative stability was observed.

Embodiment 3

[0176] preparation

[0177] The general method for preparing the formulation is by preparing the following aqueous mixture:

[0178] Solution 1: Sorbitol, Zinc Phosphate

[0179] Solution 2: TSPP, Glycerin, PEG600, Gum

[0180] Solution 3: stannous fluoride, citric acid, trisodium citrate

[0181] Solution 2 was added to solution 1. Add solution 3 to the mixture of 1 and 2. The resulting mixture is then combined with the surfactant and remaining ingredients.

[0182]Combining zinc phosphate + sorbitol mixture with TSPP, glycerol, PEG600 and gum to form a combination of zinc phosphate and TSPP, the Zn 2+ The solubility of was increased from 0.0001% to 0.12% (by mass), indicating that an initial reaction that facilitated the dissociation of the complex occurred. In solution 3, the combination of stannous fluoride and citrate probably formed multiple stannous citrate complexes. When the combined solutions 1 and 2 are mixed with solution 3, the free phosphate will now be ab...

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Abstract

Disclosed herein are high water oral care compositions comprising a stannous ion source, which compositions have improved stability. Methods of making and using the compositions are also provided.

Description

technical field [0001] The present disclosure relates to high water oral care compositions comprising stannous salts in a stabilizing base, wherein the base provides a depot for orthophosphate ions. Methods of making and using the compositions are also provided. Background technique [0002] Stannous salts such as stannous fluoride (SnF 2 ) and stannous chloride (SnCl 2 ) have been used in oral care products for many years because stannous ions have antimicrobial properties and are therefore useful in the treatment of conditions such as gingivitis. However, oral care formulations containing stannous salts have been limited due to the instability of stannous salts in aqueous solutions. Stannous salts are easily hydrolyzed when the pH is higher than 4, causing precipitation from solution, thereby losing therapeutic properties, and stannous ions (Sn 2+ ) is easy to form stannous fluoride or oxidized to form tetravalent tin (Sn 4+ ) compounds, which may stain teeth, reduce ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/20A61K8/21A61K8/24A61K8/27A61K8/365A61Q11/00A61K31/32
CPCA61Q11/00A61K8/365A61K8/21A61K8/24A61K8/27A61K8/19A61K8/20A61K2800/52A61K2800/522A61P1/02A61K33/24A61K8/345
Inventor 卡尔·迈尔斯伊拉克利斯·帕帕斯郝志刚唐赛德
Owner COLGATE PALMOLIVE CO