Selective extraction method for natural substances
A technology of natural substances and natural products, applied in the field of selective extraction of natural substances, can solve the problems of complex use conditions, long extraction time, low extraction efficiency, etc., and achieve the effect of increasing the absorption rate
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[0038] Hereinafter, according to the extraction method of the non-polar natural substance of the embodiment of the present invention, the extracted natural substance and its application will be described.
[0039] Heretofore, all terms used in this specification are only used to describe specific embodiments, not to limit the present invention. And, the singular form used herein also includes the plural form unless there is a sentence clearly expressing the opposite meaning. In addition, the meaning of "comprising" or "comprising" used in this specification refers to specifying specific characteristics, regions, integers, steps, operations, elements or components, rather than excluding other specific characteristics, regions, integers, steps, Addition of operations, elements or components.
[0040] In the present invention, terms such as first and second are used to describe various components, and the above terms are only used to distinguish one component from other componen...
Embodiment
[0092] The raw material of the natural product is goose herb, and Korean-made stone coriander (goose herb, Yongchuan) produced by Huaishan Herb Organic Agricultural Products Cooperative (https: / / natural-herb.co.kr) was purchased, washed and dried.
[0093] Use 400mL of 80% ethanol to perform hot water extraction on 10g of goose-free grass hay to obtain a primary extract. Afterwards, ethanol was removed by concentrating the primary extract under reduced pressure.
[0094] According to the composition ratio in Table 1 below, the primary extract concentrated under reduced pressure and the phase-separated composition were mixed, followed by stirring for 10 minutes. The following table 1 is related to Figure 4 The composition corresponds to the description of the composition. L1 corresponds to Example 1, L2 corresponds to Example 2, and the following are the same.
[0095] Thereafter, after standing still for 60 minutes, the phase-separated supernatant was separated. The resul...
preparation example
[0120] The supernatant (secondary extract) separated according to the above-mentioned Example 32 was concentrated (heating and natural concentration) to no more than 120% of the volume of the added lipophilic solubilizer, and 5 g of Labrasol was mixed into the concentrated supernatant as an emulsified composition to obtain Prepare microemulsions. Thus, 12 mg / mL micro emulsion (micro emulsion), 8.5 mL, 95% yield of nourishing preparation was prepared. The emulsion is water-based instead of an organic solvent, contains safe excipients, and can be used alone in various forms of products such as ointments and tonics without additional processes (preparation example 1).
[0121] Image 6Photographs were taken of the state of phase separation according to an embodiment of the invention (left) and of the final formulation microemulsified by separating the upper layer and adding mixed Labrasol (right). Image 6 The photo on the left is a photo showing the primary extract phase-separ...
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