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A traditional Chinese medicine composition with anticancer effect and anticancer traditional Chinese medicine implant

A technology of implants and compositions, applied in the field of anti-cancer traditional Chinese medicine implants, can solve the problems of low inhibition rate of lung cancer cell proliferation, unstable drug release rate of implants, etc., achieve good anti-cancer effect, good inhibitory effect, The effect of low toxic side effects

Active Publication Date: 2022-04-01
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the existing traditional Chinese medicine composition has a low inhibition rate on the proliferation of lung cancer cells and the drug release rate of the implant is unstable, and provides a Chinese medicine composition with anticancer effect and anticancer Chinese medicine Implants

Method used

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  • A traditional Chinese medicine composition with anticancer effect and anticancer traditional Chinese medicine implant
  • A traditional Chinese medicine composition with anticancer effect and anticancer traditional Chinese medicine implant
  • A traditional Chinese medicine composition with anticancer effect and anticancer traditional Chinese medicine implant

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specific Embodiment approach 1

[0027] Specific embodiment 1: The traditional Chinese medicine composition with anticancer effect in this embodiment is composed of Chinese medicine extract, Atractylodes lactone I and crocin, and the mass ratio of Chinese medicine extract, Atractylodes lactone I and crocin is 4 :1:(8~10);

[0028] The preparation method of described Chinese medicine extract is carried out according to the following steps:

[0029] 1. Weigh 2 to 10 parts of pinellia, 3 to 8 parts of gua lou, 10 to 20 parts of tangerine peel, 3 to 12 parts of scallion, 5 to 15 parts of berberine, 6 to 10 parts of Tinglizi and 3 parts by weight. ~8 parts of Baiying as raw material;

[0030] 2. Pulverize and mix the raw materials weighed in step 1 to obtain a mixture;

[0031] 3. Add distilled water and cellulase to the mixture, and perform ultrasonic enzymolysis to obtain an enzymatic solution;

[0032] 4. Add absolute ethanol to the enzymolysis solution, then let it stand at room temperature, and filter to o...

specific Embodiment approach 2

[0038] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine composition with anticancer effect is composed of Chinese medicine extract, Atractylodes lactone I and crocin, and the Chinese medicine extract, Atractylodes lactone I and crocin The mass ratio of crocin is 4:1:8.

specific Embodiment approach 3

[0039] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that: the traditional Chinese medicine composition with anticancer effect is composed of traditional Chinese medicine extract, Atractylodes lactone I and crocin, and the traditional Chinese medicine extract, Atractylodes lactone I The mass ratio of Ⅰ and crocin is 4:1:10.

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Abstract

A traditional Chinese medicine composition with anticancer effect and an anticancer traditional Chinese medicine implant, relating to a traditional Chinese medicine composition and an implant. In order to solve the problem that the existing traditional Chinese medicine composition has a low inhibition rate on the proliferation of lung cancer cells and the release rate of the implant is unstable. The traditional Chinese medicine composition is composed of traditional Chinese medicine extract, atractylodes lactone I and crocin. Preparation of the implant: dissolving PLGA and mannitol in an organic solvent, adding the traditional Chinese medicine composition, drying, forming, subpackaging and sterilizing. The auxiliary release device containing anti-cancer traditional Chinese medicine implants is composed of drug storage bins, foam plastics, sheet-shaped anti-cancer traditional Chinese medicine implants and mesh. The traditional Chinese medicine composition can inhibit the proliferation of tumor cells and has low toxic and side effects. The auxiliary release device A constant release rate is guaranteed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition with anticancer effect and an anticancer traditional Chinese medicine implant. Background technique [0002] Primary bronchial lung cancer, referred to as lung cancer, is a malignant tumor originating from the bronchial mucosa or glands. In recent years, the incidence and mortality of lung cancer have increased rapidly. Lung cancer is divided into non-small cell lung cancer and small cell lung cancer according to histopathology. Among them, non-small cell lung cancer accounts for 80% to 85% of the total number of lung cancers, including squamous cell carcinoma, adenocarcinoma, large cell carcinoma, adenosquamous carcinoma, and carcinoid. There are many ways to treat lung cancer. Although the diagnosis and treatment of lung cancer have made new progress, due to tumor metastasis and multidrug resistance, the prognosis of lung cancer patients is still poor, and the five-year survival ra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/8962A61K47/34A61K47/10A61P35/00A61K31/7024A61K31/365
CPCA61K36/8888A61K36/428A61K36/752A61K36/8962A61K36/718A61K36/31A61K36/81A61K31/365A61K31/7024A61K9/0024A61K9/204A61K9/2018A61P35/00A61K2236/19A61K2236/33A61K2300/00
Inventor 袁瑶薇刘洋王晓慧邵琪
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE