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Biomacromolecule detection method and device based on nanoparticles

A biomacromolecule and nanoparticle technology, applied in the field of biomacromolecule detection based on nanoparticles, can solve the problems of difficult and rapid detection of biomacromolecules, achieve high accuracy, high detection rate, and avoid physicochemical reactions.

Active Publication Date: 2021-08-10
NANJING UNIV OF SCI & TECH
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Problems solved by technology

[0004] This application provides a nanoparticle-based biomacromolecule detection method and device, which can be used to solve the problem that biomacromolecules are difficult to be quickly detected in a low concentration state

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  • Biomacromolecule detection method and device based on nanoparticles
  • Biomacromolecule detection method and device based on nanoparticles
  • Biomacromolecule detection method and device based on nanoparticles

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Embodiment Construction

[0048] In order to make the purpose, technical solution and advantages of the present application clearer, the implementation manners of the present application will be further described in detail below in conjunction with the accompanying drawings.

[0049] Before the method provided in this application uses a computer for data processing, it is first necessary to obtain a sample to be detected that may contain biomacromolecules to be detected.

[0050] One method provided in the embodiment of the present application is to drop the liquid to be detected on the nano-substrate, and dry the nano-substrate.

[0051] Such as figure 1As shown, it is a schematic diagram of preparing a sample to be tested provided in the embodiment of the present application. The figure includes a biomacromolecule extraction device 103 to be detected, a biomacromolecule liquid to be detected 102 and a nano-substrate 101 . Wherein, the nano-substrate 101 includes a plurality of nano-particles 1011 ....

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Abstract

The invention provides a biomacromolecule detection method and device based on nano-particles. The method provided by the invention comprises the following steps: acquiring a scattering original image corresponding to a to-be-detected biomacromolecule combined with each nano-particle on a nano-substrate; drawing an initial polarization parameter map according to light intensity change information of each pixel point in the scattering original map; performing noise reduction processing on the initial polarization parameter atlas to obtain a polarization parameter atlas to be compared; comparing the polarization parameter atlas to be compared with polarization parameter atlas in a preset database to obtain a target polarization parameter atlas consistent with the polarization parameter atlas to be compared; and according to the target polarization parameter atlas, the number of the biomacromolecules and the contrast relation between the connection positions and the polarization parameter atlas, determining the number of the biomacromolecules corresponding to each nanoparticle, and determining the number of the biomacromolecules to be detected. The method can be used for rapidly detecting low-concentration biomacromolecules.

Description

technical field [0001] The present application relates to the technical field of biological detection, in particular to a method and device for detecting biological macromolecules based on nanoparticles. Background technique [0002] Biomacromolecules include many types of molecular structures, including nucleic acids, proteins, and viruses. The identification of biological macromolecules is of great significance to the fields of medicine and biology such as DNA research, infectious animal and plant pathogens, and drug development. If the amount of biomacromolecules is weak, that is, biomacromolecules are in a low concentration state, it is difficult to be directly detected. [0003] In order to solve the problem that biomacromolecules are difficult to be detected at low concentrations, researchers have adopted a variety of solutions. However, although the current schemes have their own improvement points, most of them have the problem that the detection time is too long a...

Claims

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Application Information

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IPC IPC(8): G16B50/00G06F16/36G06N3/04G06N3/08
CPCG16B50/00G06F16/367G06N3/04G06N3/08
Inventor 刘学峰金霄张衡熊吉川刘卫平徐彬倪斌
Owner NANJING UNIV OF SCI & TECH
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