Application of a microbial plasmalogen in the treatment of colon cancer

A plasmalogen, microbial source technology, applied in applications, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as the limitations of colon cancer treatment, and achieve the effect of reducing the number and volume and inhibiting proliferation

Active Publication Date: 2022-05-06
JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for improving colon cancer, which solves the problem of treatment limitations of colon cancer

Method used

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  • Application of a microbial plasmalogen in the treatment of colon cancer
  • Application of a microbial plasmalogen in the treatment of colon cancer
  • Application of a microbial plasmalogen in the treatment of colon cancer

Examples

Experimental program
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Effect test

Embodiment 1

[0024] 1. Obtaining microbial source plasmalogens

[0025] The strains of microbial source plasmalogens are anaerobic microorganisms, including Lactobacillaceae, Bifidobacterium, Clostridium butyricum, Peptostreptococcus Kluyver and van Niel, Veillonella (Veillonella) and other plasmalogen-positive microorganisms (ie, microorganisms containing plasmalogen), a plasmalogen-positive microbial strain or a combination of microbial strains of plasmalogen-positive microorganisms;

[0026] 1) Culture Bifidobacterium longum (Bifidobacterium longum) and Clostridium butyricum (Clostridium butyricum) respectively, the inoculum amount is 0.1%, and culture them in MRS liquid medium for 24 hours, respectively collect Bifidobacterium longum and Clostridium butyricum The culture solution was centrifuged at 3500rpm / min and the cells were collected. The plasmalogen composition of the two microorganisms is shown in Table 1. The composition detection method adopts liquid chromatography-mass spect...

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Abstract

The invention discloses the application of a microbial source plasmalogen in the treatment of colon cancer, and belongs to the technical field of biomedicine and microbes. In order to provide a method for improving colon cancer. The present invention provides the application of a kind of microbial source plasmalogen in the preparation and treatment of colon cancer. extracted from a mixture. Microbial plasmalogens can reduce the expression of colon cancer-related cytokines at the molecular level, inhibit the proliferation of colon cancer cells, reduce the number and volume of colon adenomas in patients with colon cancer, and can be used as an effective nutrient for the prevention and treatment of colon cancer strategy to provide theoretical support for the efficient utilization of plasmalogen derived from gut microbes.

Description

technical field [0001] The invention relates to the application of a microbial source plasmalogen in the treatment of colon cancer, and belongs to the technical field of biomedicine and microorganisms. Background technique [0002] Colon cancer is an inherited disease that targets the tissues of the colon and is caused by mutations in specific genes that can give one cell an advantage over its neighbors. With enough mutations in certain genes, cells can become cancerous and divide uncontrollably, forming tumors. Colon cancer is now the second most common cause of cancer death in the world. Risk factors include: Family history. Inflammatory bowel disease, diabetes, low fiber and high fat diet, radiation therapy for cancer, hereditary colon cancer syndrome, etc. At present, its prevention and improvement methods are still limited, and it is the current research and industry trend to use less toxic and more natural methods, combined with current treatment methods, to treat c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/685A23K20/158A23L33/115A61P35/00
CPCA61K31/685A61P35/00A23L33/115A23K20/158A23V2002/00A23V2200/308A23V2250/18A23L33/12A61K35/742A61K35/744A61K35/745C12P7/6481C12N1/20
Inventor 刘元法刘炎峻徐勇将
Owner JIANGNAN UNIV
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