Application of macrophages in obesity treatment and blood sugar regulation

A macrophage and obesity technology, applied in the field of biomedicine, can solve the problems of difficult anti-inflammatory effects and short half-life, and achieve the effects of lowering blood sugar levels, lowering blood sugar, and reducing body weight
CN113244269APending Publication Date: 2021-08-13鲲石生物科技(深圳)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
鲲石生物科技(深圳)有限公司
Publication Date
2021-08-13

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Abstract

The invention belongs to the field of biomedicine, and particularly relates to application of macrophages expressing IL-4 protein in obesity treatment and blood sugar regulation. The application of the macrophage and a composition comprising the macrophage is as follows: (1) application in preparation of products for treating obesity; (2) application in preparation of products for reducing blood sugar; and (3) application in preparation of products for treating diabetes caused by obesity. The macrophage is a macrophage expressing an IL-4 (Interleukin-4) protein. When intraperitoneal injection is carried out on obese mice by using the prepared macrophage expressing the IL-4 protein, namely a lentivirus pCDH-IL-4 infected RAW264.7 cell, the weight of the mice can be effectively reduced, and the blood glucose level of the mice after glucose uptake is reduced. Therefore, it is proved that macrophages expressing the IL-4 protein can treat obesity and reduce blood sugar, new therapeutic drugs and methods are provided for clinically treating obesity and other diseases such as diabetes caused by obesity, and important application value is achieved for treating the obesity and other diseases such as the diabetes caused by obesity.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to the new medical application of engineered macrophages, in particular to the application of macrophages expressing IL-4 protein in treating obesity and regulating blood sugar. Background technique

[0002] With the rapid development of the economy and the acceleration of urbanization, people's lifestyle and dietary structure have undergone tremendous changes, and the overweight and obese population is increasing year by year. Studies at home and abroad have shown that obesity is an important factor in inducing hypertension, cardiovascular and cerebrovascular diseases, type 2 diabetes, hyperlipidemia, fatty liver and other diseases. A type of obesity in which fat deposition in the body begins to develop centered on the heart and abdomen is called central obesity or central obesity, which is a type of obesity that is more harmful than systemic obesity. The World Health Organization has list...

Claims

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