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Antibacterial collagen-based medical material and preparation method thereof

A base material, collagen technology, applied in the field of antibacterial collagen-based medical materials and its preparation, can solve the problems of antibiotic resistance, cytotoxicity, high cost, poor biocompatibility, etc., and achieve good antibacterial and antibacterial Function, good antibacterial and antibacterial performance, good biocompatibility effect

Inactive Publication Date: 2021-08-20
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of antibiotics can easily lead to drug resistance; metal ions (such as silver ions) may have problems such as cytotoxicity and high cost; common quaternary ammonium salts have broad-spectrum antibacterial properties, but often have poor biocompatibility; Excellent compatibility and good antibacterial properties, but poor solubility, which limits its application; plant essential oils have broad-spectrum antibacterial properties, but poor solubility and are volatile

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of dialdehyde cyclodextrin: Weigh 100 parts by weight of β-cyclodextrin and place it in a reaction kettle, add 500 parts by weight of distilled water, stir for 15 minutes to fully disperse it; use 10mM H2SO4 to adjust the pH of the solution to 2.0; add 20 parts by weight of sodium periodate, and treat it in the dark at 30°C for 3 hours; add equimolar ethylene glycol of sodium periodate, and treat it at 30°C for 15 minutes; add 1000 parts by weight of absolute ethanol , stand still, and filter; wash the precipitate repeatedly with distilled water and absolute ethanol until the AgNO3 solution checks that there is no iodide ion precipitate in the washing liquid; finally dissolve the product in distilled water, place it in a dialysis bag with a molecular weight of 100 Da, and dialyze for 24 hours at intervals Change the water for 6 hours, and dry the final product to obtain dialdehyde cyclodextrin;

[0026] (2) Preparation of antibacterial collagen-based med...

Embodiment 2

[0028](1) Preparation of dialdehyde cyclodextrin: Weigh 100 parts by weight of β-cyclodextrin into a container, add 500 parts by weight of distilled water, stir for 15 minutes to fully disperse it; use 10mM H2SO4 to adjust the pH of the solution to 2.0 Add 30 parts by weight of sodium periodate, and treat it in the dark at 35°C for 2 hours; add equimolar ethylene glycol of sodium periodate, and process it for 15 minutes at 30°C; add 1000 parts by weight of absolute ethanol, Stand still and filter; wash the precipitate repeatedly with distilled water and absolute ethanol until the AgNO3 solution checks that there is no iodide ion precipitate in the washing liquid; finally dissolve the product in distilled water and dialyze in a dialysis bag with a molecular weight of 100 Da for 48 hours at intervals of 12 Change the water every hour, and freeze-dry the final product to obtain dialdehyde cyclodextrin powder;

[0029] (2) Preparation of antibacterial collagen-based medical materi...

Embodiment 3

[0031] (1) Preparation of dialdehyde cyclodextrin: Weigh 100 parts by weight of β-cyclodextrin and place it in a reaction kettle, add 200 parts by weight of distilled water, stir for 15 minutes to fully disperse it; use 10mM H2SO4 to adjust the pH of the solution to 2.0; add 10 parts by weight of sodium periodate, and treat it in the dark at 30°C for 3 hours; add equimolar ethylene glycol of sodium periodate, and treat it at 30°C for 15 minutes; add 400 parts by weight of absolute ethanol , stand still, and filter; wash the precipitate repeatedly with distilled water and absolute ethanol until the AgNO3 solution checks that there is no iodide ion precipitation in the washing liquid; finally dissolve the product in distilled water, place it in a dialysis bag with a molecular weight of 100 Da, and dialyze for 48 hours. Change the water for 12 hours, freeze-dry the final product to obtain dialdehyde cyclodextrin powder;

[0032] (2) Preparation of antibacterial collagen-based med...

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PUM

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Abstract

The invention relates to an antibacterial collagen-based medical material and a preparation method thereof, and belongs to the field of biomedical materials. According to the antibacterial collagen-based medical material, beta-cyclodextrin is used as a raw material, and an aldehyde group derivative of beta-cyclodextrin and a plant essential oil antibacterial agent are simultaneously applied to crosslinking modification of a collagen-based material. The preparation method can improve the structural stability of materials; and on the other hand, the loaded plant essential oil antibacterial agent can endow the material with a good and lasting antibacterial function, and the preparation method is a novel preparation method of the antibacterial collagen-based medical material. The collagen-based medical material has good degradability, mechanical property and biocompatibility, further has a lasting antibacterial function, and has important clinical application value.

Description

technical field [0001] The invention relates to an antibacterial collagen-based medical material and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Collagen-based materials have been widely used in clinical operations such as the treatment of burns, head and neck repair, breast reconstruction, and abdominal wall reconstruction due to their advantages such as good biocompatibility, easy storage, wide range of indications, and promotion of wound repair. During clinical use, collagen-based materials have gradually exposed some problems. The main component of collagen-based materials is type I collagen. Under the conditions of high temperature or the presence of collagenase, the structural stability is poor, and problems such as poor mechanical properties and excessive degradation in the body may occur, which will affect the clinical treatment effect. Therefore, it is very important to carry out appropriate cross-link...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/40A61L15/46A61L15/42A61L24/00A61L24/08A61L24/10A61L27/24A61L27/20A61L27/36A61L27/50A61L27/54
CPCA61L15/325A61L15/28A61L15/40A61L15/46A61L15/42A61L24/0015A61L24/08A61L24/102A61L24/001A61L24/0005A61L27/24A61L27/20A61L27/3637A61L27/50A61L27/54A61L2400/04A61L2300/30A61L2300/404A61L2300/602C08L5/16
Inventor 但年华王璐但卫华陈一宁
Owner SICHUAN UNIV
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