Novel vaccine for preventing and treating Merkel cell carcinoma

A cell cancer, Merkel's technology, applied in the field of immunology and virology, can solve the problem of poor immune effect
CN113278634AActive Publication Date: 2021-08-20ADVACCINE SUZHOU BIOPHARMACEUTICALS CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ADVACCINE SUZHOU BIOPHARMACEUTICALS CO LTD
Publication Date
2021-08-20

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Abstract

The invention provides a novel vaccine for preventing and treating Merkel cell carcinoma. According to the novel vaccine for preventing and treating Merkel cell carcinoma, nucleotide sequences, such as SEQ ID No.1, SEQ ID No.2, SEQ ID No.3 and SEQ ID No.4, having 71.9%-74.7% homology with SEQ ID No.6 are cloned and expressed, and the vaccine based on the Merkel cell carcinoma polyoma virus capsid protein VP1 is constructed. The problems of prevention and treatment of Merkel cell carcinoma are effectively solved, and great application value and application prospects are achieved.
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Description

technical field

[0001] The invention belongs to the field of immunology and virology, in particular to a novel vaccine for preventing and treating Merkel cell carcinoma. Background technique

[0002] Merkel cell carcinoma polyomavirus (MCV) is currently the only polyomavirus that is clearly known to be directly associated with human cancer. Merkel cell carcinoma polyomavirus is a double-stranded non-enveloped DNA virus with an icosahedral spherical structure of about 45nm and a genome size of 5386bp, containing early coding regions, late coding regions and non-coding regulatory regions ( NCRR). The early genes of Merkel cell carcinoma polyomavirus mainly encode LT, ST, 57kT and ALTO (alternate frame of large T open reading frame), while the late genes mainly encode capsid proteins VP1 and VP2. VP1 has the function of initiating virus infection and often exists in the form of pentamers, and 72 pentamers can self-assemble into virus-like particles in eukaryotic systems. [...

Claims

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