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Naringenin acylhydrazone derivative with good antioxidant activity and preparation method thereof

A technology of naringenin acyl hydrazones and antioxidant activity, which is applied in the directions of anti-toxic agents, organic chemistry, and drug combination, and can solve problems such as unsatisfactory effects and inconvenient production, and achieve good effects and convenient production

Pending Publication Date: 2021-08-31
SOUTHWEST UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Anti-oxidation, anti-inflammation, and anti-cancer have always been popular research directions in the fields of modern science and medicine. The existing products that can achieve anti-oxidation, anti-inflammation, and anti-cancer effects are inconvenient to manufacture, and the effect is not ideal. How to provide an anti-oxidant Products with good oxidation, anti-inflammatory and anti-cancer effects have become a research direction

Method used

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  • Naringenin acylhydrazone derivative with good antioxidant activity and preparation method thereof
  • Naringenin acylhydrazone derivative with good antioxidant activity and preparation method thereof
  • Naringenin acylhydrazone derivative with good antioxidant activity and preparation method thereof

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Embodiment 1

[0015] A method for preparing naringenin acylhydrazone derivatives with good antioxidant activity, specifically comprising the following steps: take 0.8mmol of naringenin and 1.2mmol of hydrazide compounds, dissolve them in 18ml of ethanol, add 2.2ml of acetic acid, and Heated in a 700W microwave oven for 3 minutes to synthesize naringenin acyl hydrazone derivatives.

Embodiment 2

[0017] A preparation method of naringenin acylhydrazone derivatives with good antioxidant activity, specifically comprising the following steps: take 1.2mmol of naringenin and 0.8mmol of hydrazide compounds, dissolve them in 22ml of ethanol, add 1.8ml of acetic acid, and Heated in a 700W microwave oven for 5 minutes to synthesize naringenin acyl hydrazone derivatives.

Embodiment 3

[0019] A method for preparing naringenin acylhydrazone derivatives with good antioxidant activity, specifically comprising the following steps: take 1 mmol of naringenin and 1 mmol of hydrazide compounds, dissolve them in 20 ml of ethanol, add 2 ml of acetic acid, and place them in a 700W microwave oven Heated for 4 minutes to synthesize naringenin acylhydrazone derivatives.

[0020] The obtained derivative of the present invention is measured in vitro antioxidant activity experiment with ABTS, FRAP, DPPH three kinds of methods as follows:

[0021] 1. Determination of antioxidant activity in vitro by ABTS method: The method of reference (Qingzhu Huaa, 2018) was used to determine the antioxidant activity of naringenin derivatives and BHT food additives. Take 0.01 mmol of all the samples, dissolve them in 10 ml of DMF to obtain a 1 mM solution, and set aside. Dilute the 10mM Trolox solution in the kit to 1.5, 1.2, 0.9, 0.6, 0.3, 0.15mM. The total antioxidant activity was deter...

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Abstract

The invention relates to a naringenin acylhydrazone derivative with good antioxidant activity and a preparation method thereof. The preparation method specifically comprises the following steps of: taking and dissolving 0.8-1.2 mmol of naringenin and 0.8-1.2 mmol of a hydrazide compound in 18-22 ml of ethanol, adding 1.8-2.2 ml of acetic acid, heating in a 700 W microwave oven for 3-5 min, and synthesizing to obtain the naringenin acylhydrazone derivative. The preparation method has the advantages that the preparation is convenient, the in-vitro antioxidant activity and effect of the obtained derivative are good, the antioxidant activity of the derivative is equivalent to that of an existing food additive, and the derivative can be further studied as an anti-inflammatory and anti-cancer drug.

Description

technical field [0001] The invention relates to a naringenin acylhydrazone derivative with good antioxidant activity and a preparation method thereof. Background technique [0002] Anti-oxidation, anti-inflammation, and anti-cancer have always been popular research directions in the fields of modern science and medicine. The existing products that can achieve anti-oxidation, anti-inflammation, and anti-cancer effects are inconvenient to manufacture, and the effect is not ideal. How to provide an anti-oxidant Products with good oxidation, anti-inflammatory and anti-cancer effects have become a research direction. Contents of the invention [0003] The object of the present invention is to provide a kind of naringenin acylhydrazone derivatives with good antioxidant activity and its preparation method, so as to solve the problems raised in the above-mentioned background technology. [0004] In order to solve the above-mentioned technical problems, the technical solution prov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/68A61P39/06
CPCC07D311/68A61P39/06
Inventor 董家吏苏学素焦必宁
Owner SOUTHWEST UNIVERSITY
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