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Multi-scale optical fiber fluorescence microscopic imaging system

A microscopic imaging, multi-scale technology, applied in fluorescence/phosphorescence, material analysis through optical means, measurement devices, etc., can solve the problem of blood drug concentration, pharmacokinetics can not explain drug pharmacological effects, reflection, etc. question

Pending Publication Date: 2021-09-14
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, more and more studies have shown that traditional pharmacokinetics cannot well explain the pharmacological effects of some drugs, especially for some special tissues and organs (such as tumors), and how the drugs exert their pharmacological effects is still unclear. The drug concentration is difficult to fully and accurately reflect the drug effect
Throughout the research status at home and abroad, no instrument can meet the needs of multi-scale pharmacokinetic research in living animals

Method used

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  • Multi-scale optical fiber fluorescence microscopic imaging system
  • Multi-scale optical fiber fluorescence microscopic imaging system
  • Multi-scale optical fiber fluorescence microscopic imaging system

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Embodiment Construction

[0045] The present invention will be further described below in conjunction with embodiment, but protection scope of the present invention is not limited to this:

[0046] 1. Product structure. combine figure 1 , a multi-scale optical fiber fluorescence microscopy imaging system, which includes laser fusion and light splitting optical paths, fluorescence intensity monitoring channels, tissue imaging channels, and target cell imaging channels, wherein:

[0047] The laser fusion and light splitting optical path includes 488nm laser, 650nm laser, optical shutter, long-pass dichroic mirror, and optical path system. The light emitted by the 488nm laser enters the first long-pass through the first optical shutter SH1 and the first mirror M1 in sequence. Dichroic mirror DM1, the light emitted by the 650nm laser enters the first long-pass dichroic mirror DM1 through the second shutter SH2; the fusion light of the first long-pass dichroic mirror DM1 is divided into three paths throug...

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Abstract

The invention discloses a multi-scale optical fiber fluorescence microscopic imaging system. The multi-scale and multi-wavelength fluorescence microscopic system with an optical fiber fluorescence probe with three different resolutions is applied to research on concentration dynamic change of drugs in blood / tissues, distribution of main metabolic organs and transfer characteristics in target cells, and particularly to high-resolution microscopic imaging of transfer and release characteristics in the target cells. According to the invention, the multi-scale optical fiber fluorescence microscopic imaging system is applied to in-vivo pharmacokinetic research, so that the influence of various random errors can be eliminated, pharmacokinetic behaviors can be reflected more accurately, and the correlation among multiple parameters is more credible, thereby truly and systematically revealing the in-vivo transport mechanism of drugs in small animals.

Description

technical field [0001] The invention belongs to the field of microscopic imaging, in particular to a multi-scale optical fiber fluorescence microscopic imaging system. Background technique [0002] The long drug R&D cycle and low clinical transformation efficiency are fundamentally due to the lack of a preclinical druggability evaluation system. The pharmacokinetic properties of a drug are closely related to its efficacy, toxicity and side effects, and are the key to evaluating the possibility of its clinical transformation. In the basic research of the preclinical in vivo kinetic properties of drugs, it is not only necessary to investigate the dynamic distribution properties in the blood, but also to reveal the accumulation of drugs in the main metabolic organs (liver, kidney, etc.), the damage of organ tissues, and the damage of target cells. dynamic distribution characteristics. Although various in vivo imaging systems (CT, MRI, PET, SPECT, etc.) can show that the drug ...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N21/01
CPCG01N21/6428G01N21/6458G01N21/6486G01N21/01G01N2021/0112
Inventor 顾月清林巧屈军乐钱志余
Owner CHINA PHARM UNIV
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