Methods of making and using universal centralized influenza vaccine genes

Abstract

This disclosure describes a number of different polypeptide sequences, and the nucleic acid sequences encoding such polypeptide sequences, that can be used alone or in combination as universal vaccines (e.g., against influenza A or influenza B in humans or influenza in swine).

Description

Technical field [0001] The present disclosure generally relates to vaccines and specifically involves influenza vaccines. Background technique [0002] In 1931, the influenza virus was identified as a pathogen of the pig. Two years later, in 1933, the flu virus was found in humans. [0003] Every year, 5% -15% of the world's population are affected by epidemics and have upper respiratory tract infections, and 3 million to 5 million have severe diseases, and 250,000 to 500,000 cases lead to death (WHO 2009). In the United States, the annual seasonal influenza has a population of 20%, leading to 200,000 hospitalization and approximately 37,000 deaths. The World Health Organization (WHO) pointed out that "the flu is quickly spread to the world with seasonal epidemics, and has caused considerable economic burden in the form of hospitals and other health care costs and productivity. In the United States of America, it is estimated that every year The popular cost is as high as 167 bil...

AI Technical Summary

Problems solved by technology

However, when associated with other pathogens of porcine respiratory disease syndrome, IAV-S infection of pigs often results in severe pneumonia and even death

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