Preparation method of liposome emulsion
A liposome and emulsion technology, which is applied in the directions of liposome delivery, medical preparations containing inactive ingredients, and medical preparations containing active ingredients, etc., can solve problems such as environmental pollution, product solvent residues, and impact on product quality, etc., To achieve the effect of simple preparation equipment and process, safe and environmentally friendly production process, and high product safety
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Embodiment 1
[0069] In this embodiment, the preparation formula of glabridin liposome is shown in Table 1, and the specific preparation steps are as follows:
[0070] (1) Add phospholipids (PC95%), glabridin and cholesterol to the prescribed amount of water, heat in a water bath at 60°C, and use an experimental IKA high-speed shear disperser to shear at a speed of 10,000 rpm for 60 minutes to obtain a uniform emulsion.
[0071] (2) Homogenize the homogeneous emulsion obtained in the step (1) under high pressure, and circulate twice under the pressure of 400 / 600 / 800 / 1000 bar respectively to obtain uniform glabridin liposomes.
[0072] Such as Figure 12 As shown, the particle size of the liposomes in the emulsion obtained in step (1) of this example is about 10 to 20 microns, indicating that the high-speed shear sample has not reached the nanometer level at this time, and the fat-soluble drug is emulsified and dissolved in the in the water.
[0073] From figure 1 It can be seen that afte...
Embodiment 2
[0075] In this embodiment, the preparation formula of glabridin liposome is shown in Table 1, and the specific preparation steps are as follows:
[0076] (1) Add phospholipids (PC95%), glabridin and cholesterol to the prescribed amount of water, heat in a water bath at 60°C, and use an experimental IKA high-speed shear disperser to shear at a speed of 10,000 rpm for 60 minutes to obtain a uniform emulsion.
[0077] (2) Homogenize the homogeneous emulsion obtained in the step (1) under high pressure, and circulate twice under the pressure of 400 / 600 / 800 / 1000 bar respectively to obtain uniform glabridin liposomes.
[0078] From figure 2 It can be seen that after high-speed shearing in step 1, a liposome-like multilayer spherical structure can be observed in the emulsion in step 1.
[0079] Such as Figure 13 As shown, the particle size of the liposomes in the emulsion obtained in step (1) of this example is about 4 to 10 microns, indicating that the high-speed shear sample ha...
Embodiment 3
[0081] In this embodiment, the preparation formula of glabridin liposome is shown in Table 1, and the specific preparation steps are as follows:
[0082] (1) Add phospholipids (PC95%), glabridin and cholesterol to the prescribed amount of water, heat in a water bath at 60°C, and use an experimental IKA high-speed shear disperser to shear at a speed of 10,000 rpm for 60 minutes to obtain a uniform emulsion.
[0083] (2) Homogenize the homogeneous emulsion obtained in the step (1) under high pressure, and circulate twice under the pressure of 400 / 600 / 800 / 1000 bar respectively to obtain uniform glabridin liposomes.
[0084] From image 3 It can be seen that after high-speed shearing in step 1, a liposome-like multilayer spherical structure can be observed in the emulsion in step 1.
[0085] Such as Figure 14 As shown, the particle size of the liposomes in the emulsion obtained in step (1) of this example is about 4 to 8 microns, indicating that the high-speed shear sample has ...
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Abstract
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