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Composite nanofiber membrane containing periplaneta americana herb residue polysaccharide, and preparation method and application of composite nanofiber membrane

A technology of composite nanofibers and Periplaneta americana, which is applied in the fields of medical formula, medical science, drug delivery, etc., can solve the problems of failure to realize the comprehensive utilization and development of drug dregs resources, waste of resources, etc., and achieve the benefits of cell growth, Easy to transport, speed up the effect of blood vessels

Inactive Publication Date: 2021-10-08
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the survey found that Periplaneta americana is currently the most widely used insect traditional Chinese medicinal material. The production process of preparations such as Kangfuxin Liquid produces a large amount of medicinal residues after alcohol extraction. Currently, this part of medicinal residues is extensively piled up, fermented, and made into animal feed. In particular, water-soluble macromolecular substances such as polysaccharides cannot be reused, and the comprehensive utilization and development of medicinal dregs resources have not been realized, resulting in a huge waste of resources

Method used

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  • Composite nanofiber membrane containing periplaneta americana herb residue polysaccharide, and preparation method and application of composite nanofiber membrane
  • Composite nanofiber membrane containing periplaneta americana herb residue polysaccharide, and preparation method and application of composite nanofiber membrane
  • Composite nanofiber membrane containing periplaneta americana herb residue polysaccharide, and preparation method and application of composite nanofiber membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The extraction of embodiment 1 Periplaneta americana dregs polysaccharide

[0030] Step 1. Weigh 100 g of Periplaneta americana dregs after alcohol extraction, dry the dregs of Periplaneta americana after alcohol extraction at 40°C for 48 hours, pulverize and pass through a 40-mesh sieve; add Soak in petroleum ether for 24 hours, remove fat-soluble components, concentrate under reduced pressure to collect petroleum ether, repeat twice, dry the degreased Periplaneta americana dregs at 50°C to obtain Periplaneta americana dregs powder;

[0031] Step 2, according to the mass ratio of material to liquid of 1:10, add distilled water to the Periplaneta americana dregs powder obtained in step 1, reflux and extract at a temperature of 80° C. for 120 min, repeat this twice, and filter to obtain a mixed solution;

[0032] Step 3, adjust the pH of the mixed solution obtained in step 2 to neutral, centrifuge and filter, concentrate the supernatant, add 4 times the volume of ethanol...

Embodiment 2

[0035] Embodiment 2 Preparation of composite nanofiber membrane containing Periplaneta americana dregs polysaccharide

[0036] Prescription: 0.1 part of Periplaneta americana dregs polysaccharide prepared in Example 1, 100 parts of silk fibroin / gelatin mixture (wherein the mass ratio of silk fibroin to gelatin is 1: 3);

[0037] The preparation method is:

[0038] S1. Dissolving the polysaccharide of Periplaneta americana dregs in hexafluoroisopropanol to obtain a hexafluoroisopropanol solution with a mass fraction of 8% polysaccharide of Periplaneta americana dregs; dissolving the silk fibroin / gelatin mixture in hexafluoroisopropanol Virahol, the hexafluoroisopropanol solution that obtains massfraction as 4% silk fibroin / gelatin;

[0039] Add the hexafluoroisopropanol solution of polysaccharide from Periplaneta americana to the hexafluoroisopropanol solution of silk fibroin / gelatin, and dissolve it after stirring for 7 hours at a rate of 400rpm to obtain a spinning solution;...

Embodiment 3

[0041] Example 3 Preparation of Composite Nanofiber Membrane Containing Periplaneta americana Dregs Polysaccharide

[0042] Prescription: 0.5 parts of Periplaneta americana dregs polysaccharide prepared in Example 1, 100 parts of a mixture of silk fibroin / gelatin (wherein the mass ratio of silk fibroin to gelatin is 1: 3);

[0043] Preparation:

[0044] S1. Dissolving the polysaccharide of Periplaneta americana dregs in hexafluoroisopropanol to obtain a hexafluoroisopropanol solution with a mass fraction of 8% polysaccharide of Periplaneta americana dregs; dissolving the mixture of silk fibroin and gelatin in hexafluoroisopropanol Fluoroisopropanol, obtaining mass fraction is the hexafluoroisopropanol solution of 4% silk fibroin / gelatin;

[0045] Add the hexafluoroisopropanol solution of the polysaccharide of Periplaneta americana to the hexafluoroisopropanol solution of silk fibroin / gelatin, and dissolve it after stirring for 10 h at a rate of 1000 rpm to obtain a spinning sol...

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Abstract

The invention provides a composite nanofiber membrane containing periplaneta americana herb residue polysaccharide. The composite nanofiber membrane is prepared from the periplaneta americana herb residue polysaccharide and a mixture of silk fibroin and gelatin. The invention also provides a preparation method, which comprises the following steps of: dissolving the periplaneta americana herb residue polysaccharide in hexafluoroisopropanol to obtain a hexafluoroisopropanol solution of the periplaneta americana herb residue polysaccharide, dissolving the mixture of silk fibroin and gelatin in hexafluoroisopropanol to obtain a silk fibroin / gelatin hexafluoroisopropanol solution, performing stirring and dissolving to obtain a spinning solution, spinning the spinning solution to obtain the composite nanofiber membrane by adopting an electrostatic spinning method, and performing vacuum drying to obtain the composite nanofiber membrane containing the periplaneta americana herb residue polysaccharide. The invention further provides application of the composite nanofiber membrane containing the periplaneta americana herb residue polysaccharide; and the composite nanofiber membrane containing the periplaneta americana herb residue polysaccharide is applied to wound dressing. The composite nanofiber membrane containing the periplaneta americana herb residue polysaccharide in the invention is used for wound dressing, can also provide a wet environment, provides a barrier function similar to skin for a wound, effectively absorbs wound exudate and promotes tissue regeneration, and has huge advantages in chronic skin ulcers.

Description

technical field [0001] The invention belongs to the technical field of nanofiber membranes, and in particular relates to a composite nanofiber membrane containing polysaccharides from Periplaneta americana, a preparation method and application thereof. Background technique [0002] Periplaneta americana was first used as medicine in "Shen Nong's Materia Medica", called "cockroach", "Shen Nong's Materia Medica" listed it as a middle-grade product, "taste: salty, cold; treatment: blood stasis, cold and heat, broken stagnation, throat Closed, internal cold and childless". Periplaneta americana has been used for wound repair for a long time, and there are many records in modern pharmaceutical classics and ethnic medicine classics. "Yunnan Provincial Standards of Chinese Medicinal Materials" (Volume 1) records that cockroaches have the effects of invigorating the spleen and eliminating malnutrition, promoting blood circulation and promoting blood circulation, diuresis and detume...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/42A61L15/44A61L15/62D04H1/728D04H1/42
CPCA61L15/28A61L15/32A61L15/42A61L15/425A61L15/44A61L15/62D04H1/728D04H1/42A61L2400/12A61L2300/232A61L2300/41C08L5/00C08L89/00
Inventor 吴亿晗章津铭张晨王婷成颜芬庞兰廖倩
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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