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Application of dahurian patrinia herb in preparation of methicillin-resistant staphylococcus epidermidis resisting medicine

A Staphylococcus epidermidis, anti-methicillin technology, applied in the field of medicine

Pending Publication Date: 2021-10-15
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no report of Patrinia being used for the antibacterial application of methicillin-resistant Staphylococcus epidermidis

Method used

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  • Application of dahurian patrinia herb in preparation of methicillin-resistant staphylococcus epidermidis resisting medicine
  • Application of dahurian patrinia herb in preparation of methicillin-resistant staphylococcus epidermidis resisting medicine
  • Application of dahurian patrinia herb in preparation of methicillin-resistant staphylococcus epidermidis resisting medicine

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] In order to verify the effect, the applicant has done research on the antibacterial effect of Patrinia on methicillin-resistant Staphylococcus epidermidis, and the results are as follows:

[0021] 1. Acquisition of methicillin-resistant Staphylococcus epidermidis

[0022] In this experiment, a strong induction method in vitro (such as figure 1 shown), using methicillin as an inducing drug, the method of strong induction was used to obtain methicillin-resistant Staphylococcus epidermidis.

[0023] Firstly, the drug was diluted in multiples, and the concentration from high to low was 8MIC (4μg / mL), 4MIC (2μg / mL), 2MIC (1μg / mL), 1MIC (0.5μg / mL), 1 / 2MIC (0.25μg / mL) and 1 / 4MIC (0.125μg / mL).

[0024] The overnight culture of Staphylococcus epidermidis was then diluted 1.0 × 10 5 ~1.0×10 6 cfu mL -1 , inoculate it in a sterile 96-well plate, 180 μL per well.

[0025] Finally, the diluted drug was aseptically added to each well in turn, mixed evenly, and incubated for 24...

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Abstract

The invention discloses application of dahurian patrinia herb to preparation of a medicine for resisting methicillin-resistant staphylococcus epidermidis, the medicine for resisting methicillin-resistant staphylococcus epidermidis is prepared by taking dahurian patrinia herb or a dahurian patrinia herb extract as a raw material, the minimum inhibitory concentration of the dahurian patrinia herb extract to the methicillin-resistant staphylococcus epidermidis is 2.5 mg / mL, and the minimum bactericidal concentration of the dahurian patrinia herb extract to the methicillin-resistant staphylococcus epidermidis is 20 mg / mL. According to the application disclosed by the invention, the new application of the herba patriniae in preparing the medicine for treating and resisting the methicillin-resistant staphylococcus epidermidis is found for the first time, a new medication way is brought for clinically treating infection caused by the methicillin-resistant staphylococcus epidermidis, and the application has important clinical significance for preventing and treating infection caused by the methicillin-resistant staphylococcus epidermidis.

Description

technical field [0001] The invention relates to the application of Patrinia in the preparation of anti-Methicillin-resistant Staphylococcus epidermidis, belonging to the technical field of medicine. Background technique [0002] Bacterial infection is an infection caused by pathogenic bacteria or conditional pathogenic bacteria invading the body to grow and reproduce, and produce toxins and other metabolites. It is one of the main factors that endanger human health. In recent years, with the frequent use of antibiotics and antibacterial drugs, drug-resistant bacteria continue to emerge. The infection caused by methicillin-resistant Staphylococcus epidermidis (MRSE) is almost all over the world, and its drug resistance is mainly manifested as resistance to multiple antibacterial drugs, which brings difficulties to clinical treatment. [0003] Patrinia, the dried whole plant of Patrinaceae plant Patriniae. Cool in nature, pungent and bitter in the mouth. It has the effects ...

Claims

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Application Information

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IPC IPC(8): A61K36/84A61P31/04
CPCA61K36/84A61P31/04A61K2236/331A61K2236/39A61K2236/53A61K2236/51
Inventor 刘鑫张宁彭玮周永辉杨雨齐安丽丽罗宁宁李春燕邹松岐
Owner 贵州中医药大学
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