50 results about "Meticillin resistance" patented technology

Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant Staphylococcus aureus (MRSA). Disclosed are methods and compositions based on DNA sequences for the specific detection of MREJ sequences designated types xi, xii, xiii, xiv, xv, xvi, xvii, xviii, xix, and xx for diagnostic purposes and/or epidemiological typing.

A 2-arylmethylazetidine carbapenem derivative of formula (I) or a pharmaceutically acceptable salt thereof exhibits a wide spectrum of antibacterial activities against Gram-positive and Gram-negative bacteria and excellent antibacterial activities against resistant bacteria such as methicillinresistant Staphylococcus aureus (MRSA) and quinolone-resistant strains (QRS).

The invention discloses a cyclic hexapeptide compound desotamide A4 and an application thereof in preparation of antibacterial drugs. The structural formula of the compound desotamide A4 is as shown in formula (I) . The cyclic hexapeptide desotamide A4 disclosed by the invention has a broad-spectrum anti-gram pathogenic bacterium effect. The test result shows that the desotamide A4 has good inhibitory activity (MIC is 8-32 [mu] g/mL) on a plurality of clinical drug-resistant staphylococcus aureus, enterococcus faecalis, micrococcus luteus, bacillus subtilis, simulated staphylococcus and staphylococcus haemolyticus including methicillin-resistant staphylococcus aureus; compared with an unmodified parent natural cyclic peptide compound desotamide A, the activity of the cyclic hexapeptide desotamide A4 disclosed by the invention is enhanced by 2-4 times, and the cyclic hexapeptide desotamide A4 has an important value in research and development of antibacterial drugs.

The present invention discloses 5-arylamino quinolyl-7, 8-dione derivative with the chemical structure expression as shown. The present invention also relates to the synthesis and application in preparing antibiotic medicine, especially medicine for antagonizing methicillin resisting Staphylococcus aureus (MRSA), of the derivative. Experiment shows that the 5-arylamino quinolyl-7, 8-dione derivative has obvious bacteriostasis effect on some Gram positive bacteria, especially on methicillin resisting Staphylococcus aureus (MRSA), and may be used in preparing effective antibiotic medicine.

The invention discloses a method for rapidly preparing a Fascaplysin derivative through a Suzuki-Miyaura coupling reaction and an application of the Fascaplysin derivative in resisting methicillin-resistant staphylococcus aureus (MRSA ATCC43300), and particularly discloses a method for rapidly preparing the Fascaplysin derivative through the Suzuki-Miyaura coupling reaction. The preparation method comprises the following steps: (1) carrying out regioselective Suzuki-Miyaura coupling on phenylboronic acid or heterocyclic boronic acid with different substituent groups and a dihalo-substituted raw material substrate, so as to obtain a series of Fascaplysin derivative precursor compound beta-carboline; and (2) carrying out intramolecular ring closing reaction on beta-carboline through high-temperature reaction, so as to obtain a series of Fascaplysin derivatives. According to the preparation method disclosed by the invention, a Fascaplysin derivative compound library with structural diversity can be quickly and efficiently constructed, and compared with the traditional Fascaplysin derivative synthesis, the preparation time is greatly shortened, and the synthesis efficiency is improved. The synthesized Fascaplysin derivative shows strong antibacterial activity, inhibits the formation of a biological membrane, and is an antibacterial drug candidate compound with a good application prospect.

The invention relates to a method for detection of a methicillin resistant coagulase positive Staphylococcus aureus (MRSA) strain by means of a sequence specific amplification reaction.