Fascaplysin derivative, preparation method and application of Fascaplysin derivative in MRSA (Methicillin Resistant Staphylococcus Aureus) resistance
A technology of derivatives and reactions, applied in antibacterial drugs, organic chemistry, etc., to achieve the effect of convenient and fast synthesis methods
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[0048] The present invention will be further described in detail below with reference to the accompanying drawings.
[0049] In the following embodiments, the same or similar reference numerals are initially, the same or similar original, or the original, as described below, and the embodiments described below are exemplary, only to explain the present invention, and cannot be understood In order to limit the invention.
[0050] The experimental test of the present application and the description of the drawings are as follows.
[0051] The FascaplySin derivative in this application is prepared by the following methods. (1) Put the raw material substrate dual halide β-pyramine compound (6-bromo-9H-pyridine [3,4-B] indole-1-yl) (2-chlorophenyl) meandenophenone, organic boric acid and The base is weighed in a certain molar ratio, and under an inert gas protection, a certain proportion of catalyst is added, and finally the reaction solvent is added, and the stirring is heated for a c...
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