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Application of clemastine fumarate in preparation for resisting methicillin-resistant staphylococcus aureus (MRSA)

A technology of clemastine fumarate and staphylococcus, which is applied in the direction of antibacterial drugs, medical preparations containing active ingredients, active ingredients of heterocyclic compounds, etc., can solve problems such as adverse reactions and side effects, and achieve good inhibitory effect, High safety and good clinical response

Active Publication Date: 2020-11-13
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Vancomycin, which has a good curative effect on MRSA infection, has a large number of adverse reactions and side effects when used

Method used

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  • Application of clemastine fumarate in preparation for resisting methicillin-resistant staphylococcus aureus (MRSA)
  • Application of clemastine fumarate in preparation for resisting methicillin-resistant staphylococcus aureus (MRSA)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1. Materials

[0050] 1.1 Drugs and main reagents

[0051] Clemastine fumarate, Meilun Biotechnology Co., Ltd. (Dalian);

[0052] Calcium-adjusted MH Broth Medium (CAMHB), Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0053] MHA agar medium, Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong); normal saline, Meilun Biotechnology Co., Ltd. (Dalian);

[0054] 1.2 Experimental strains

[0055] MRSA6 strain isolated and identified by Microbiology Laboratory of Qilu Children's Hospital of Shandong University

[0056] 1.3 Instruments

[0057] Electronic balance (AUY120), SHIMADZU CORPORATION (Japan);

[0058] Bacteria collection ring, Huanyao Pharmaceutical Equipment Sales Co., Ltd. (Beijing, China);

[0059] McFarney Turbidimetric Tube, Kangtai Biotechnology Company (Zhejiang, China);

[0060] Vortex mixer (G-560E), Si company (USA);

[0061] Hot air disinfection box (GRX-9123A), MMM company (Ge...

Embodiment 2

[0076] Example 2 Determination of the dynamic action of clemastine fumarate against MASA

[0077] 1. Materials

[0078] 1.1 Drugs and main reagents

[0079] Clemastine fumarate, Meilun Biotechnology Co., Ltd. (Dalian);

[0080] Calcium-adjusted MH Broth Medium (CAMHB), Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0081] MHA agar medium, Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong); normal saline, Meilun Biotechnology Co., Ltd. (Dalian);

[0082] 1.2 Experimental strains

[0083] MASA1 isolated from the microbiology laboratory of Qilu Children's Hospital of Shandong University.

[0084] 1.3 Instruments

[0085] Electronic balance (AUY120), SHIMADZU CORPORATION (Japan);

[0086] Bacteria collection ring, Huanyao Pharmaceutical Equipment Sales Co., Ltd. (Beijing, China);

[0087] McFarney Turbidimetric Tube, Kangtai Biotechnology Company (Zhejiang, China);

[0088] Vortex mixer (G-560E), Si c...

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Abstract

The invention particularly relates to an application of clemastine fumarate in an anti-MRSA preparation. The MRSA has high toxicity, shows drug resistance to most clinically common antibiotic drugs, is widely distributed in a daily environment, and is a troublesome pathogenic strain. In order to develop an active substance with an inhibition effect on the drug-resistant bacteria, the invention screens and verifies that the clemastine fumarate has a good inhibition effect on MRSA from clinical drugs, and is expected to be applied to the development of anti-MRSA infection related drugs.

Description

technical field [0001] The invention belongs to the technical field of antibacterial preparations, and in particular relates to the application of clemastine fumarate in preparation of anti-methicillin-resistant Staphylococcus aureus preparations. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] In recent years, due to the wide application and irrational use of antibiotics, some common clinical pathogens have developed severe drug resistance, and the level of drug resistance has been increasing, and multi-drug resistant strains have emerged, which has brought great harm to human health. Drug-resistant bacterial infection has become a major challenge in the current medical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61K45/06A61P31/04
CPCA61K31/40A61K45/06A61P31/04
Inventor 李秀云王艳欣盖中涛郝丽娜张乐海王世富
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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