The invention discloses a pesticide composition containing pyrazosulfuron-ethyl and difenoconazole and belongs to the technical field of pesticide. The pesticide composition is compounded and prepared from the following effective ingredients: abamectin, pyrazosulfuron-ethyl, fluorine silicon iodine, sodium humate, 1,2-dibenzoyl-1-tert-butylhydrazine, trifloxysulfuron sodium, ethirimol, coumaphos, merida, a benzenesulfonic acid emulsifier and a benzene solvent. When a finished product of the pesticide composition is prepared, following auxiliary agents of the pesticide composition containing the pyrazosulfuron-ethyl and the difenoconazole, a dispersing agent, an additive, simethicone and water are needed, and a weight ratio of the abamectin to the pyrazosulfuron-ethyl to the 1,2-dibenzoyl-1-tert-butylhydrazine is 10 to 4 to 1. According to the pesticide composition, the two kinds of pesticides with completely different action mechanisms are mixed to achieve combined action on pests from multiple aspects to achieve the purpose of effectively preventing the pests; meanwhile, a use amount of the pesticides in fields is reduced, economical cost is saved, pollution of the pesticides to environment is reduced, and risk that the pests generate resistance to the pesticides is also reduced.