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A method of antibiotic-loaded bifunctional active nanofiber membrane to prevent and control environmental microbial pollution

A nanofiber membrane, microbial contamination technology, applied in the fields of botanical equipment and methods, chemicals for biological control, biocides, etc. The effect of addressing churn and reducing the risk of resistance

Inactive Publication Date: 2017-09-22
彭可扬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a chemical agent, antibiotics will not affect their antibacterial efficacy after immobilization, and solve the shortcomings of being unable to be recycled and easily lost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Dissolve 1.3g of polylactic acid particles with a molecular weight of 100,000 and 0.2g of polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer in 10g of dichloromethane, mix evenly and stir until clear, and take 0.4g of kana Mymycin and 0.2 g of itraconazole were dissolved in 0.4 mL of deionized water. Stir vigorously to form an emulsion, and mix it with 2 mL of an aqueous solution containing 25% glutaraldehyde cross-linking agent, and the resulting precursor solution is ready to use under constant stirring.

[0023] The precursor solution is introduced into the electrospinning device to be spun. The electrospinning device consists of a high-voltage DC power supply (DW-P503-1ACF7, Dongwen, Tianjin), a peristaltic pump (BF300, Qili, Baoding), a plastic syringe, and 9# stainless steel. It consists of a needle and a Φ3mm polytetrafluoroethylene pipeline. Connect the negative electrode of the power supply to the filter screen of the air conditioner (Gree, KFR-2...

Embodiment 2

[0026] The same amount of F108 was used as the emulsifier to prepare the immobilized antibiotic active electrospun fiber membrane, and the Haier KFRd-23 air conditioner was treated with antibacterial treatment. The rest of the conditions were the same as in Example 1. No microorganisms could be detected after 15 days of cultivation.

Embodiment 3

[0028]The same amount of F127 was used as the emulsifier to prepare the immobilized antibiotic active electrospun fiber membrane, and the Haier KF-26GW air conditioner was treated with antibacterial treatment. The rest of the conditions were the same as in Example 1. No microorganisms could be detected after 15 days of cultivation.

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Abstract

The invention relates to a method for preventing and controlling environmental microbial pollution by an antibiotic-loaded bifunctional active nanofiber membrane. The method includes the preparation of electrospun fiber membrane and the process of using it to inhibit the growth of microorganisms; using the immobilized antibiotic active electrospun fiber membrane prepared by different emulsifiers to inhibit the growth of microorganisms in air conditioners of different specifications, the results show that the The method combines the electrospinning technology and the combined use of antibiotics, which has a highly effective antibacterial effect, and solves the shortcomings of it cannot be recycled and easily lost. With the help of in-situ high-voltage electrospinning technology, electrospun active fiber membranes can be loaded on the surface and inside of indoor electrical appliances to achieve functional protection of key positions prone to pathogenic microorganisms, providing long-lasting, durable and stable Antibacterial and sterilizing ability.

Description

technical field [0001] The invention belongs to the technical field of environmental microorganism control, and in particular relates to a method for immobilizing various antibiotics for indoor microbial pollution prevention and control. Background technique [0002] The pollution degree of air microorganisms such as bacteria and fungi is one of the important parameters for evaluating indoor air quality. Indoor air microbial contamination can cause eye irritation, asthma, atopic dermatitis, hypersensitivity pneumonitis, and infectious diseases. Indoor building materials and household appliances are the main sources of indoor air pollution. They can not only release harmful chemicals to the human body, but also provide favorable conditions for the growth of microorganisms; develop practical indoor air antibacterial technology to inhibit building The growth of microorganisms such as materials, household appliances, household products, etc., to reduce the potential pollution s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/653A01N43/16A01N25/10A01P1/00A01P3/00D04H1/4326D04H1/435D04H1/728D01D5/00
Inventor 彭可扬
Owner 彭可扬
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