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Anti-proliferative composition

A composition and compound technology, applied in the direction of drug combination, active ingredients of hydroxy compounds, food science, etc., can solve problems such as lack of ordinary technical personnel

Inactive Publication Date: 2005-05-11
NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These studies and others suggest that some botanical components may act as active anti-proliferative agents, but teach the skilled artisan nothing as to where to target the various components during the cycle of proliferating cells and which combinations may enhance the overall efficacy of the therapy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Compositions for treating prostate cancer

[0072] Mix the following ingredients:

[0073] Ingredient Amount per day (mg)

[0074] Soy Isoflavones 100.0

[0075] Lycopene 15.0

[0076] Silymarin 160.0

[0077] Antioxidants

[0078] Vitamin C 225.0

[0079] Vitamin E 75.0

[0080] Carotenoids 3.0

[0081] Flavonoids 19.0

[0082] Ubiquinol 4.0

[0083] Selenium 0.128

[0084] Zinc 18.0

[0085] Copper 2.7

[0086] Magnesium 5.0

[0087] Riboflavin 2.5

[0088] Vitamin B6 3.3

[0089] Vitamin B12 0.0033

[0090] Folic acid 0.4

[0091] N-acetyl-cysteine ​​500

Embodiment 2

[0093] Compositions for the treatment of colon cancer

[0094] Mix the following ingredients:

[0095] Ingredient Amount per day (mg)

[0096] Soy Isoflavones 25.0

[0097] Lycopene 2.0

[0098] Silymarin 50.0

[0099] Fiber Mix 15000

[0100] Calcium 1500

[0101] Probiotics

[0102] Lactobacillus rhamnosus (Lb.rhamnosus) + Lactobacillus alcoholophilus (Lb.acidophilus)

[0103] 2-41010CFU

[0104] Antioxidants

[0105] Vitamin C 150.0

[0106] Vitamin E 37.5

[0107] Carotenoids 1.5

[0108] Flavonoids 10.0

[0109] Ubiquinol 2.0

[0110] Selenium 0.085

[0111] Zinc 9.0

[0112] Copper 1.4

[0113] Magnesium 2.5

[0114] Riboflavin 1.3

[0115] Vitamin B6 1.3

[0116] Vitamin B12 1.6

[0117] Folic acid 0.4

[0118] Green Tea Extract 300.0

[0119] Curcumin 60.0

Embodiment 3

[0121] 45g regular chocolate bar. The ingredients are: syrup, milk powder, chocolate pieces, cocoa butter, soybean lecithin and flavorings, wherein 1g of syrup is replaced by glycerin, and 1.5g of chocolate pieces are replaced by 50mg of milk thistle, 20mg of apigenin and 20mg of lycopene.

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PUM

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Abstract

Prophylaxis and treatment of estrogen-independent hyperproliferation of cells in animals or humans by means of a pharmaceutical or nutritional composition comprising a) two or more inhibitors of the G1 / S phase of the cell cycle and b) two or more inhibitors of the G2 / M phase of the cell cycle; and c) at least three components of the two or more protein tyrosine kinase inhibitors. In particular, component a) includes two or more compounds selected from flavonoids, carotenoids, and isoflavones; component b) includes compounds selected from flavonoids, hydroxylated stilbenes, isogenistein, and celery Two or more compounds of aglycone; component c) includes two or more compounds selected from flavonoids and isoflavones.

Description

field of invention [0001] The present invention relates to the use of a composition comprising a combination of inhibitors of different phases of the cell cycle and inhibitors of protein tyrosine kinases for the prevention and treatment of hyperproliferation of cells. Furthermore, the present invention also relates to compositions having these antiproliferative properties. Background of the invention [0002] In many cases, cellular hyperproliferation is an extremely undesirable process in humans and animals that leads to a variety of serious and sometimes fatal diseases. The most prominent of these diseases is cancer. Cancer accounts for a substantial portion of all human deaths in the world. For example, in the United States, 1.2 million new cases of invasive cancer are diagnosed each year, and approximately 500,000 people die from cancer each year. Cancer is the second leading cause of death and is expected to overtake heart disease in the early 21st century to rank fi...

Claims

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Application Information

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IPC IPC(8): A61K45/00A23L23/00A23L33/105A23L33/135A23L33/15A23L33/16A23L33/21A61K31/07A61K31/366A61K36/48A61K45/06A61P13/08A61P17/06A61P35/00
CPCA61K36/28A61K36/736A61K36/889A61K45/06A23L23/00A23L33/105A23L33/135A23L33/15A23L33/16A23L33/21A61P13/08A61P17/06A61P35/00
Inventor 阿德里亚努斯·兰伯特斯·贝特霍尔德斯·范海尔沃尔特克拉斯克·范诺伦罗伯特·约翰·约瑟夫·哈格曼温迪·安托瓦妮特·维尔维利根米瑞恩·兰辛克
Owner NUTRICIA
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