Ultrasonic system for predicting curative effect of ICC immunotherapy combined with targeting and/or chemotherapy

Abstract

The invention relates to an ultrasonic system for predicting the curative effect of ICC immunotherapy combined with targeting and / or chemotherapy, and the system is characterized in that the system comprises: a gray-scale ultrasonic image obtaining module which is used for obtaining a gray-scale ultrasonic image of the maximum section of a focus; an ICC focus segmentation module; the feature extraction module that is used for carrying out feature extraction on the focus ROI region; a feature dimension reduction module; the radiomics prediction model that predicts key feature data after immunotherapy combined targeting and / or chemotherapy treatment of a patient. Ultrasonic is a first-line iconography method for liver examination at present, and is also the most common iconography method for ICC preoperative evaluation and curative effect follow-up visit. The imaging omics can extract massive high-throughput characteristics, and by combining conventional gray-scale images and clinical data of patients and establishing an imaging omics model based on the high-throughput characteristics, immunotherapy combined targeting and / or chemotherapy curative effect prediction of the ICC patients can be realized.

Description

technical field [0001] The present invention relates to an ultrasound system for predicting the efficacy of immunotherapy combined with targeting and / or chemotherapy for intrahepatic cholangiocarcinoma ("ICC" for short). Background technique [0002] Intrahepatic cholangiocarcinoma accounts for about 15%-20% of liver cancer, and its incidence has been gradually increasing in recent years. Surgical resection is the only potential curative treatment, but the rate of surgical resection is low, only 10%-20% of confirmed cases have the chance of surgical resection. The postoperative recurrence and metastasis rate is high, and high-risk recurrence factors include positive surgical margins, lymph node metastasis, invasion of blood vessels and nerve bundles, preoperative CA19-9 levels, large tumors, and multiple tumors. Its 5-year survival rate is <5%. Immunotherapy combined with targeting and / or chemotherapy is the direction of advanced ICC treatment, and it is expected to bec...

AI Technical Summary

Problems solved by technology

Surgical resection is the only potential curative treatment, but the rate of surgical resection is low, only 10%-20% of confirmed cases have the chance of surgical resection

At present, there is no technology to combine gray-scale ultrasound images of ICC with radiomics analysis methods to establish an AI model to predict the efficacy of immunotherapy combined with targeted and / or chemotherapy in ICC patients

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