1, 2, 3-triazolopyrimidine compound and preparation method and application thereof

A compound, C1-C4 technology, applied in the direction of organic chemistry, drug combination, pharmaceutical formulation, etc., can solve the problem of lack of similar compounds and so on
CN113549080AActive Publication Date: 2021-10-26INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
Publication Date
2021-10-26

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Abstract

The invention discloses a compound and a preparation method thereof, wherein the compound is shown as a formula I and can inhibit secretion of inflammasome nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) and interleukin-1beta (IL-1beta). ELISA experiments show that the compound can significantly inhibit the activity of NLRP3 and reduce the expression of NLRP3 downstream inflammatory factors IL-1beta. The compound shown in the formula I is expected to become a novel anti-inflammatory drug and an autoimmune disease treatment drug.
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Description

technical field

[0001] The invention belongs to the field of medical technology, and relates to a preparation method and application of a class of 1,2,3-triazolopyrimidine small molecule compounds, in particular to a novel nucleotide binding oligomerization inhibitor capable of inhibiting inflammasomes Small-molecule drugs for domain-like receptor protein 3 (NLRP3) and interleukin-1β (IL-1β), methods for preparing the compound, and the compound as an inflammasome nucleotide-binding oligomerization domain-like receptor Application of body protein inhibitor or interleukin-1β inhibitor drug in preparation of anti-inflammatory drug and autoimmune disease drug. Background technique

[0002] The following background introduction related to the present invention is used to help the understanding of the present invention, but should not be considered as the prior art of the present invention. All cited publications are incorporated by reference in full.

[0003] It is well known t...

Claims

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