A kind of method of NFSI-catalyzed synthesis of asymmetric disulfide derivatives

Abstract

The invention belongs to the field of fine chemicals, and relates to a method for synthesizing asymmetric disulfide derivatives catalyzed by NFSI, comprising the following steps: adding NFSI, symmetric disulfide A and symmetric disulfide B into reaction solvents 1, 2 In the sealed tube of dichloroethane, react at 25~80 ℃, finish the reaction after 1~8 hours of reaction, and obtain the asymmetric disulfide derivative through separation and purification, wherein NFSI, symmetric disulfide A and the symmetric disulfide B in a molar ratio of 0.1:1.0:1.0. The method can efficiently synthesize asymmetric disulfide derivatives without using expensive rhodium metal catalysts and unpleasant thiols.

Description

technical field [0001] The invention belongs to the field of fine chemicals and relates to a method for catalyzing and synthesizing asymmetric disulfide derivatives by NFSI. Background technique [0002] Asymmetric disulfides are an important class of sulfur-containing organic compounds, which are widely found in various natural products, medicines, foods and materials with medicinal activity. Therefore, how to directly and efficiently synthesize such compounds has attracted great attention of chemists. There are two main methods for preparing asymmetric disulfides. The first one uses two different mercaptans as raw materials to synthesize asymmetric disulfides by oxidative dehydrogenation. The disadvantage of such methods is that the smell of mercaptans is unpleasant. At the same time, this type of reaction will self-coupling to obtain a symmetrical disulfide; the second uses a disulfanyl reagent to react with a nucleophile under the action of a transition metal catalyst t...

AI Technical Summary

Problems solved by technology

There are two main methods for the preparation of asymmetric disulfides. The first method uses two different mercaptans as raw materials to synthesize asymmetric disulfides by oxidative dehydrogenation. The disadvantage of this method is that the mercaptans have an unpleasant smell. , at the same time, this type of reaction will undergo self-coupling to obtain a symmetrical disulfide; the second type uses a disulfide reagent to react with a nucleophile under the action of a transition metal catalyst to obtain the target product. The defect of this type of reaction mainly lies in the use of metal Catalyst, does not meet the characteristics of green environmental protection

In addition, the use of transition metal rhodium catalysts can also realize the exchange reaction between symmetrical disulfide compounds to synthesize asymmetric disulfide derivatives, but the application of this strategy is limited due to the use of expensive rhodium catalysts.

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