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Hydroxypropyl methylcellulose hollow capsule and preparation process thereof

A technology of hypromellose and hydroxypropyl methylcellulose, which is applied in the field of hypromellose hollow capsules and their preparation, can solve the problems of incomplete dissolution of hypromellose and low energy consumption, and achieves No food safety risk, ingredient safety effect

Pending Publication Date: 2021-11-05
ANHUI HUANGSHAN CAPSULE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a hollow hypromellose capsule and its preparation process. The hollow capsule can ensure that the problem of incomplete dissolution of hypromellose can be solved without producing appearance defects such as transparent spots, and can Low energy consumption, safe ingredients, no harm to the human body, no food safety risk at all, disintegration time limit within 10 minutes, reaching the disintegration performance of gelatin empty capsules, and meeting the requirements of preparations

Method used

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  • Hydroxypropyl methylcellulose hollow capsule and preparation process thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0022] Low-temperature hypromellose hollow capsule production process, weighing the following components: hydroxypropyl methylcellulose 10kg, carrageenan (BL9002) 140g, carrageenan (BLI 1120) 30g, potassium chloride 35g, sodium acetate 35g , polyethylene glycol 6008g, 15°C purified water 45kg.

[0023] The above-mentioned low-temperature hypromellose hollow capsule production process comprises the following steps:

[0024] Step 1, weigh the following components in parts by weight: hydroxypropyl methylcellulose 10kg, carrageenan (BL9002) 140g, carrageenan (BLI 1120) 30g, potassium chloride 35g, sodium acetate 35g, polyethylene glycol Alcohol 6008g, 15°C purified water 45kg.

[0025] Step 2, weigh 35kg of purified water at 15°C, add the full amount of hydroxypropyl methylcellulose and polyethylene glycol 600, and stir continuously at 15°C for 2 hours until it dissolves into a transparent glue ①;

[0026] Step 3, weigh 8kg of purified water, add the full amount of carrageenan (...

Embodiment 2

[0030] Low-temperature hypromellose hollow capsule production process, weighing the following components: hydroxypropyl methylcellulose 10kg, carrageenan (BL9002) 170g, carrageenan (BLI 1120) 20g, potassium chloride 44g, sodium acetate 44g , polyethylene glycol 6008g, 25°C purified water 45kg.

[0031] The above-mentioned low-temperature hypromellose hollow capsule production process comprises the following steps:

[0032] Step 1, weigh the following components in parts by weight: hydroxypropyl methylcellulose 10kg, carrageenan (BL9002) 170g, carrageenan (BLI 1120) 30g, potassium chloride 44g, sodium acetate 44g, polyethylene glycol Alcohol 6008g, 25°C purified water 45kg.

[0033] Step 2, weigh 35kg of purified water at 25°C, add the full amount of hydroxypropyl methylcellulose and polyethylene glycol 600, and stir continuously at 25°C for 2 hours until it dissolves into a transparent glue ①;

[0034] Step 3, weigh 8kg of purified water, add the full amount of carrageenan (...

Embodiment 3

[0038] Low-temperature hypromellose hollow capsule production process, weighing the following components: hydroxypropyl methylcellulose 10kg, carrageenan (BL9002) 180g, carrageenan (BLI 1120) 40g, potassium chloride 40g, sodium acetate 40g , polyethylene glycol 6008g, 30°C purified water 45kg.

[0039] The above-mentioned low-temperature hypromellose hollow capsule production process comprises the following steps:

[0040] Step 1, weigh the following components in parts by weight: hydroxypropyl methylcellulose 10kg, carrageenan (BL9002) 180g, carrageenan (BLI 1120) 40g, potassium chloride 40g, sodium acetate 40g, polyethylene glycol Alcohol 6008g, 30°C purified water 45kg.

[0041] Step 2, weigh 35kg of purified water at 30°C, add the full amount of hydroxypropyl methylcellulose and polyethylene glycol 600, and stir continuously at 35°C for 2 hours until it dissolves into a transparent glue ①;

[0042] Step 3, weigh 8kg of purified water, add the full amount of carrageenan (...

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Abstract

The invention discloses a hydroxypropyl methylcellulose hollow capsule and a preparation process thereof. The hydroxypropyl methylcellulose hollow capsule is prepared from the following raw materials in parts by weight: 1000 parts of hydroxypropyl methylcellulose, 14-21 parts of mixed carrageenan, 4-10 parts of a mixed coagulant, 6000-10 parts of polyethylene glycol and 4000-5000 parts of purified water. The mixed carrageenan is prepared from the following substances in parts by weight: 12-16 parts of carrageenan BL9002 and 2-5 parts of carrageenan BLI 1120. The mixed coagulant is prepared from the following substances in parts by weight: 2-5 parts of potassium chloride and 2-5 parts of sodium acetate. According to the production process of the hydroxypropyl methylcellulose hollow capsule by the low-temperature method, the hollow capsule can ensure that the problem that the hydroxypropyl methylcellulose is not completely dissolved can be solved, appearance defects such as transparent points cannot be generated, the components are safe, the hydroxypropyl methylcellulose hollow capsule is harmless to a human body and has no edible safety risk, and the disintegration time is within 10 minutes.

Description

technical field [0001] The invention relates to the technical field of hollow capsules, in particular to a hypromellose hollow capsule and a preparation process thereof. Background technique [0002] The main raw material of hypromellose hollow capsules is hydroxypropyl methylcellulose (HPMC), also known as hypromellose, cellulose hydroxypropyl methyl ether, which is made of highly pure cotton cellulose. It is produced by etherification under alkaline conditions. At present, HPMC is mainly used to disperse HPMC at a high temperature of 80-85 °C, supplemented by auxiliary materials such as carrageenan and gellan gum to produce capsules. Due to the thermal coagulation temperature of HPMC, it needs to be dissolved at low temperature, which is generally impossible to achieve in the actual production of hollow capsules. The temperature is suitable for the complete dissolution of hypromellose, so hypromellose will not completely dissolve and agglomerate, which will cause appearan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/36A61K47/10A61K47/12A61K47/02
CPCA61K9/4816
Inventor 柳有成张志强强鹏斌何成彭明芳黄丽娟贺旭
Owner ANHUI HUANGSHAN CAPSULE CO LTD
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