Application of compounds in preparation of medicine for treating and/or preventing demyelination diseases

A technology for demyelinating diseases and compounds, applied in the directions of active ingredients of heterocyclic compounds, drug combinations, nervous system diseases, etc., can solve the problems of hindering and unable to promote the repair of remyelination nerve axons, etc., and achieve the recovery of nerve function decline. Effect

Active Publication Date: 2021-11-09
SUN YAT SEN UNIV SHENZHEN +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

But under pathological conditions, this process is hindered
Current therapeutic modalities targeting the immune system reduce immune-mediated damage in demyelinating diseases, but fail to promote remyelination and axonal repair

Method used

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  • Application of compounds in preparation of medicine for treating and/or preventing demyelination diseases
  • Application of compounds in preparation of medicine for treating and/or preventing demyelination diseases
  • Application of compounds in preparation of medicine for treating and/or preventing demyelination diseases

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Embodiment

[0025] Promoting effect of compounds of formula I to formula V on differentiation of oligodendrocyte precursor cells (OPC)

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Abstract

The invention provides application of compounds in preparation of a medicine for treating and/or preventing demyelination diseases. The compounds of a formula I to a formula V can be used for promoting differentiation and myelination of oligodendroglia precursor cells to oligodendroglia cells by inhibiting TM7SF2 to improve accumulation of FF-MAS in a cholesterol metabolic pathway; and original oligodendroglia precursor cells in a brain of a patient suffering from the demyelination diseases are promoted to be differentiated into the oligodendroglia cells to form myelin sheaths to wrap axons again, so that neurological function decline caused by the loss of the myelin sheaths is recovered, and the compounds have the effects of treating and/or relieving and/or preventing the demyelination diseases.

Description

technical field [0001] The invention belongs to the technical field of new applications of compounds, and in particular relates to the application of compounds in the preparation of drugs for treating and / or preventing demyelinating diseases. Background technique [0002] In the vertebrate central nervous system (Central nervous system, CNS), axonal myelination realizes jumping conduction of nerve impulses and accelerates the conduction speed of nerve impulses. Oligodendrocytes (Oligodendrocyte, OL) and Schwann cells (Schwann cell) produce the myelin sheath of the central nervous system and peripheral nervous system (peripheral nervous system, PNS), respectively. Among them, OL is produced by differentiation of oligodendrocyte precursor cells (OPC). Multiple sclerosis (MS), Guillain-Barre syndrome (Guillain-Barresyndrome), optic neuromyelitis (Neuro myelitis optica, NMO) and other demyelinating diseases can cause damage and demyelination of nerve axons , resulting in neuro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/498A61K31/4245A61K31/52A61K31/513A61K31/522A61P25/28A61P25/00
CPCA61P25/00A61P25/28A61K31/52A61K31/498A61K31/4245A61K31/513A61K31/522Y02A50/30
Inventor 邓文斌张豪杰郭莹刘焕彬高宏
Owner SUN YAT SEN UNIV SHENZHEN
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