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Composition for treatment and / or prevention of infectious hoof diseases

A composition and infectious technology, applied in the direction of anhydride/acid/halide active ingredients, drug delivery, organic active ingredients, etc., can solve the problems that cannot meet the needs of animal husbandry, disadvantages, etc.

Pending Publication Date: 2021-11-09
NUTRITION SCI N V
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The impending development of resistance of pathogenic organisms to antibiotic therapy and the toxicity of current alternatives poses a major disadvantage to current methods of treatment and prevention
In addition, antibiotic treatment carries the risk of transfer of antibiotic substances into products of animal origin
[0007] Therefore, current methods do not meet the needs of the livestock industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1: Disinfectant activity of compositions of embodiments of the invention

[0065] Dichelobacter nodosus, formerly known as Bacteroides nodosus, is a Gram-negative obligate anaerobic bacterium belonging to the family Cardiobacteriaceae. It has polar pili and is the causative agent of sheep foot rot and interdigital dermatitis.

[0066] The "minimum inhibitory concentration" or "MIC" was determined for a composition comprising 90% of the MCFA moiety (of which 50% caprylic acid, 30% capric acid, and 20% lauric acid) and 10% CA moiety (including citric acid). ". As used herein, MIC refers to the lowest concentration of a compound or composition that prevents measurable growth of bacteria.

[0067] Equal amounts of CFU of Artiodactyla nodosum were plated on appropriate growth media containing 0% (control), 0.5%, 1.5%, 2.5%, 5% or 50% dilutions of the above compositions.

[0068] No growth inhibition of Artiodactyla nodosum was observed under the control condition...

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PUM

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Abstract

The current invention provides a composition for use in the topical treatment and / or prevention of infectious hoof diseases in an animal, wherein composition comprises a medium-chain fatty acid (MCFA) fraction comprising one or more MCFAs and / or derivatives thereof. In a second aspect, the invention provides a method for disinfecting the hoofs of an animal comprising the step of topically administering a composition comprising an MCFA fraction to said animal, wherein said MCFA fraction comprises one or more MCFAs and / or derivatives thereof. In a final aspect, the invention provides a disinfectant composition comprising an MCFA fraction and acarboxylic acid (CA) fraction, wherein said MCFA fraction comprises MCFAs and / or derivatives thereof, and said CA fraction comprises one or more carboxylic acids.

Description

technical field [0001] The present invention relates to compositions for the treatment and / or prevention of infectious hoof disease in animals, and methods of using such compositions to improve animal husbandry performance. Background technique [0002] Infectious diseases of the hooves such as hairy hoof warts (papillomatous dermatitis), hoof rot (interdigital cellulitis) and stable hoof rot (interdigital dermatitis) in such conditions as sheep, goats, horses, cows and Common in farm animals such as beef cattle. [0003] Dactylitis is a disease that causes lameness in cattle. It is an infectious disease caused by a variety of different bacteria and has been described around the world, mainly in high-density captive and intensive dairy production systems. [0004] Symptoms of dactylitis include decreased mobility, lifting the affected leg, walking with the toes down, severe lameness, and decreased milk production. These symptoms have adverse effects on animal welfare and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/20A61K45/06A61P31/04A61K9/00A61K31/194
CPCA61K9/0017A61K31/19A61K31/194A61K31/20A61K2300/00A61P31/04A61K45/06
Inventor G·布鲁格曼R·布鲁格
Owner NUTRITION SCI N V
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