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Application of compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester in medicine

A technology of methyl caffeoyl quinic acid and compound, which is applied in the directions of drug combination, medical preparation containing active ingredients, antipyretic drug, etc., to achieve the effect of inhibiting secretion and inhibiting cell damage

Inactive Publication Date: 2021-11-26
SHENZHEN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are very few studies involving the compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester, and only the relevant activity is a preliminary study for neuroprotection. So far, there is no compound Application of 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester anti-inflammatory active ingredient in medicine

Method used

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  • Application of compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester in medicine
  • Application of compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester in medicine
  • Application of compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester in medicine

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Embodiment

[0026] Application of a compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester in medicine, the compound 4-O-feruloyl-5-O-caffeoylquinate having the following chemical structural formula Acid methyl ester (molecular formula: C 27 h 28 o 12 ):

[0027]

[0028] Used in the preparation of medicines with anti-inflammatory and antioxidant activities.

[0029] The compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester can eliminate the increase of NO level induced by LPS and IFN-γ, inhibit the gene expression level of inflammatory factors, and effectively inhibit the M1 type of macrophages Polarization; clarified the effect of the anti-inflammatory active ingredient of compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester on the phosphorylation level and nuclear translocation of proteins related to MAPK signaling pathway; confirmed that the compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester regulates the MAPK signaling pathway by targeting TAK1, regulates ...

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Abstract

The invention discloses application of a compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester in medicine. The compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester (molecular formula: C27H28O12) is applied to preparation of anti-inflammatory and antioxidant activity medicine. According to the application of the compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester in medicine, the influence of the compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester on the phosphorylation level and nuclear shift of MAPK signal pathway key protein is provided; the compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester can inhibit the ROS level induced by LPS and IFN-gamma through an NRF2 / HO-1 pathway; that the compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester regulates the MAPK signal pathway through targeted TAK1 and regulates macrophage M1 type differentiation is proved, and therefore secretion of inflammatory mediators is inhibited; and cell damage caused by oxidative stress is inhibited by enhancing nuclear shift of NRF2 and the transcription level of HO-1, and a foundation is laid for application of anti-inflammatory and antioxidant active ingredients in medicine.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a compound 4-O-feruloyl-5-O-caffeoylquinic acid methyl ester in medicine. Background technique [0002] Inflammation is a chain reaction of the immune system after the body is induced by stimuli, and belongs to the physiological response of self-protection in the immune response. Among the stimuli that cause inflammation, lipopolysaccharide (LPS) is a component of the outer membrane of the cell wall of Gram-negative bacilli. As an innate immune inducer, it can activate immune responses and induce infectious inflammation. When LPS binds to the pattern recognition receptor Toll-like receptor 4 on the cell membrane to form a complex, it activates the adapter protein myeloid differentiation protein (MyD88), and transmits the stimulus to a series of downstream proteins and related kinases, thereby regulating the expression of inflammatory factors secretion, leadin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P29/00A61P39/06
CPCA61K31/216A61P29/00A61P39/06
Inventor 曾小斌江园园葛岚岚姚杰谢秋杰缪雨阳刘晨霄
Owner SHENZHEN PEOPLES HOSPITAL