Multi-groove microneedle array, preparation method thereof and biological detection microneedle sensor

Abstract

The invention relates to a multi-groove microneedle array, a preparation method thereof and a biological detection microneedle sensor. The multi-groove microneedle array comprises a needle membrane and a needle body on the front side of the needle membrane, micropores are formed in the needle membrane, microgrooves extending in the length direction of the needle body are formed in the side wall of the needle body, each micropore corresponds to one microgroove, and the micropores are located in inner cavity areas of the microgrooves and form a liquid guide channel with inner cavities of the microgrooves. The biological detection microneedle sensor comprises the multi-groove microneedle array and biological detection test paper. The preparation method of the multi-groove microneedle array comprises the steps of preparing the needle membrane and a photoetching mask, and preparing the multi-groove microneedle array in a self-aggregation photoetching mode. The multi-groove microneedle array has the beneficial effects that more liquid guiding channels can be arranged on the needle body with limited volume, so that the efficiency of extracting tissue fluid is improved; the microgrooves are provided with side openings, so that compared with a hollow channel in the needle body, the problem of blockage of the liquid guide channels is not prone to occurring; and meanwhile, the preparation method is simple in process, low in cost and beneficial to popularization.

Description

technical field [0001] The invention relates to the field of microneedle technology, in particular to a multi-groove microneedle array, a preparation method thereof, and a biological detection microneedle sensor. Background technique [0002] Glucose monitoring is a part of everyday life, especially for people with diabetes. The most common way to determine blood sugar levels is by pricking your finger with a lancet and dropping the blood on a glucose test strip. The main disadvantages of glucose test strips are: the pain of using a lancet to draw blood and skin damage. [0003] Microneedle is a micron-scale three-dimensional array structure, which has received extensive research and attention because of its safety and painless advantages. Microneedles can be used for both transdermal drug delivery and interstitial fluid extraction. Using the microneedle array for blood glucose detection does not require blood collection, and can directly measure the glucose content in th...

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is: the extraction liquid efficiency of the existing microneedle array, and the preparation cost is high

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