Process for preparing sulodexide raw material
A preparation process and process technology, applied in the field of sulodexide raw material production, can solve the problems affecting the extraction of sulodexide substances, low purity of sulodexide raw materials, unsuitable for industrialized production, etc. Amplified, practical effect
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Embodiment 1
[0025] A kind of technique for preparing sulodexide raw material, concrete preparation process steps are as follows:
[0026] Step 1: adding chondroitin sulfate, dermatan sulfate, nucleic acid and heparin sodium to the mixed solution of heparin sodium to better separate heparin sodium from impurities, and collecting the precipitate to obtain a crude heparin sodium solution;
[0027] Step 2: under low temperature conditions, adjust the pH value of the crude heparin sodium aqueous solution to acidity, centrifuge at low temperature, and collect the supernatant to obtain a sulfated polysaccharide solution;
[0028] Step 3: Add 1 kg of sulfated polysaccharide solution, add water to dissolve to 5-15% mmol / L, add calcium chloride to make the concentration 1-10 mmol / L (preferably 4 mmol / L), add magnesium sulfate to make the magnesium ion concentration 1-10 mmol / L L (preferably 2-5mmol / L), add sodium chloride to make the concentration 0.1%~1.5%mmol / L (preferably 0.3-0.5%mmol / L), use el...
Embodiment 2
[0040] A kind of technique for preparing sulodexide raw material, concrete preparation process steps are as follows:
[0041] Step 1: adding chondroitin sulfate, dermatan sulfate, nucleic acid and heparin sodium to the mixed solution of heparin sodium to better separate heparin sodium from impurities, and collecting the precipitate to obtain a crude heparin sodium solution;
[0042] Step 2: under low temperature conditions, adjust the pH value of the crude heparin sodium aqueous solution to acidity, centrifuge at low temperature, and collect the supernatant to obtain a sulfated polysaccharide solution;
[0043] Step 3: 1 kg of sulfated polysaccharide solution, add water to dissolve to 5-15% mmol / L, add sodium chloride to make the concentration 1-10 mmol / L (preferably 4 mmol / L), add magnesium sulfate to make the magnesium ion concentration 1-10 mmol / L L (preferably 2-5mmol / L), add sodium chloride to make the concentration 0.1%~1.5%mmol / L (preferably 0.3-0.5%mmol / L), use electri...
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