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Motherwort fruit characteristic chromatogram and construction method thereof, stachydrine hydrochloride content determination method, motherwort fruit formula granule and preparation method thereof

A technology of stachydine hydrochloride and a construction method, which is applied in the field of traditional Chinese medicine detection, can solve the problems of complex method, large energy consumption, inability to comprehensively evaluate different origins, etc. Loss, high accuracy effect

Active Publication Date: 2021-12-07
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003]Therefore, the technical problem to be solved in the present invention is to overcome the existing technology can not comprehensively evaluate the quality of Fructus Fructus of different origins and the problem of threonine hydrochloride content in Fructus Fructus of measuring The method is complicated, the energy loss is large and other defects, thus providing a characteristic map and its construction method of the formula granules, decoction pieces, freeze-dried powder or medicinal materials of Fructus Fructus, and a method for determining the content of stachydrine hydrochloride in Fructus Fructus

Method used

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  • Motherwort fruit characteristic chromatogram and construction method thereof, stachydrine hydrochloride content determination method, motherwort fruit formula granule and preparation method thereof
  • Motherwort fruit characteristic chromatogram and construction method thereof, stachydrine hydrochloride content determination method, motherwort fruit formula granule and preparation method thereof
  • Motherwort fruit characteristic chromatogram and construction method thereof, stachydrine hydrochloride content determination method, motherwort fruit formula granule and preparation method thereof

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Effect test

Embodiment 1

[0066] This embodiment provides a method for constructing a characteristic map of the freeze-dried powder of Fructus Chickens, comprising the following steps,

[0067] (1) Preparation of reference substance solution: get stachydrine hydrochloride, add 70% ethanol to make every 1ml contain 0.2mg stachydrine hydrochloride reference substance solution;

[0068] Preparation of the test solution: Get 0.1g of the lyophilized powder of Azurite chinensis, grind it finely, accurately weigh it, put it in a conical flask, add 10ml of 70% ethanol aqueous solution precisely, seal it tightly, weigh it, and test it at a power of 500W, frequency Ultrasonic treatment at 40kHz for 30min, let cool, weigh again, make up the lost weight with 70% ethanol aqueous solution, shake well, filter through 0.22μm microporous membrane, take the filtrate, and obtain.

[0069] (2) Accurately draw 10 μ L of need testing solution and reference substance solution respectively and inject into high performance liq...

Embodiment 2

[0075] This embodiment provides a method for constructing a characteristic map of the freeze-dried powder of Fructus Chickens, comprising the following steps,

[0076] (1) Preparation of reference substance solution: get stachydrine hydrochloride, add 70% ethanol to make every 1ml contain 0.23mg stachydrine hydrochloride reference substance solution;

[0077] Preparation of the test solution: Get 0.1g of the lyophilized powder of Azurite chinensis, grind it finely, accurately weigh it, put it in a conical flask, add 10ml of 70% ethanol aqueous solution precisely, seal it tightly, weigh it, and test it at a power of 500W, frequency Ultrasonic treatment at 40kHz for 30min, let cool, weigh again, make up the lost weight with 70% ethanol aqueous solution, shake well, filter through 0.22μm microporous membrane, take the filtrate, and obtain.

[0078] (2) Accurately draw 10 μ L of need testing solution and reference substance solution respectively and inject into high performance li...

Embodiment 3

[0080] The present embodiment provides a method for constructing a feature map of ziweizi decoction pieces, including the following steps,

[0081] (1) Preparation of reference substance solution: get stachydrine hydrochloride, add 70% ethanol to make every 1ml contain 0.2mg stachydrine hydrochloride reference substance solution;

[0082] Preparation of the test solution: Take 1g of the decoction pieces of Azusa subtilis, accurately weigh it, put it in a conical flask, accurately add 10ml of 70% ethanol aqueous solution, seal it tightly, weigh it, and ultrasonically process it at a power of 500W and a frequency of 40kHz Let it cool for 30 minutes, weigh again, make up the lost weight with 70% ethanol aqueous solution, shake well, filter through a 0.22 μm microporous membrane, take the filtrate, and obtain the product.

[0083] (2) Accurately draw 10 μ L of need testing solution and reference substance solution respectively and inject into high performance liquid chromatograph,...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly relates to a motherwort fruit characteristic spectrum and a construction method thereof, a stachydrine hydrochloride content determination method, a motherwort fruit formula granule and a preparation method thereof. By controlling the gradient program, the reliable, stable and good-repeatability motherwort fruit characteristic chromatogram can be constructed by adopting a specific method, and a more scientific, reasonable and detailed basis is provided for quality control of motherwort fruits. According to the construction method, the peak appearance time is changed by adjusting the flow rate, the operation time is shortened, the method is easy to operate and implement, information of characteristic peaks of the motherwort fruits can be fully reflected, chemical component characteristics of the motherwort fruits can be displayed, good separation degree and peak shapes of main components can be kept, the motherwort fruits from different producing areas and the quality of the motherwort fruits can be comprehensively evaluated, and the method is rapid and effective.

Description

technical field [0001] The invention belongs to the technical field of detection of traditional Chinese medicines, and in particular relates to a characteristic map of Fructus Radix and its construction method, a method for determining the content of stachydrine hydrochloride, formula granules of Fructus Radix and a preparation method thereof; more specifically, it relates to Fructus Fructus The characteristic map of formula granules, decoction pieces, freeze-dried powder or medicinal materials and its construction method, the determination method of stachydrine hydrochloride content in Ziweizi, and the formula granules of Ziweizi and its preparation method. Background technique [0002] Leonurus japonicus Houtt. is the dried and mature fruit of Leonurus japonicus Houtt., a plant of the Labiatae family. It has the effects of promoting blood circulation and regulating menstruation, clearing liver and improving eyesight. It is a commonly used gynecological traditional Chinese m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/54G01N30/74A61K36/533A61K9/16A61K131/00
CPCG01N30/02G01N30/06G01N30/54G01N30/74A61K36/533A61K9/1652A61K9/1682A61K2236/331A61K2236/39A61K2236/51Y02A50/30
Inventor 张志强张宁张建辉程立伟周永康付静
Owner BEIJING KANGRENTANG PHARMA
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