Magnetic nanoparticle imaging method and system based on non-uniform excitation field

Abstract

The invention belongs to the technical field of biomedical imaging, particularly relates to a magnetic nanoparticle imaging method and system based on a non-uniform excitation field, and aims to solve the problems that the magnetic nanoparticle imaging view is small and the application range is limited due to the fact that the excitation limitation of a uniform magnetic field cannot be overcome in the prior art. The method comprises the following steps of separating the non-uniform excitation magnetic field into independent space and current time functions through a space-time separation method; calculating a normalized signal peak value through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak value and the imaging subunit volume; and in combination with the normalized signal peak value, the excitation magnetic field non-uniform space function and the reconstruction mathematical model, quantitatively reconstructing spatial distribution of nanoparticles, and realizing magnetic nanoparticle imaging of an object to be reconstructed. According to the invention, artifact errors caused by non-uniform excitation magnetic fields can be reduced, the precision and resolution of images are effectively improved, the power consumption is low, the maintenance cost is low, and the implementation process is convenient and simple.

Description

technical field [0001] The invention belongs to the technical field of biomedical imaging, and in particular relates to a magnetic nanoparticle imaging method and system based on a non-uniform excitation field. Background technique [0002] Magnetic nanoparticles are nanoscale particles with superparamagnetic properties. In recent years, they have been widely studied and applied as a new type of medical imaging tracer in clinical problems such as tumor detection, magnetic particle hyperthermia, and targeted drug delivery. . [0003] The magnetic nanoparticle imaging (MPI) method is to control the gradient magnetic field with high field strength to encode the entire imaging field of view, and at the same time apply a high-frequency uniform excitation magnetic field to excite the magnetic nanoparticles to generate a nonlinear response, and finally use the response voltage detected by the receiving coil The signal is imaged. Traditional magnetic nanoparticle imaging uses a un...

AI Technical Summary

Problems solved by technology

[0007] In order to solve the above-mentioned problems in the prior art, that is, the prior art cannot overcome the limitation of uniform magnetic field excitation, so that the magnetic nanoparticle imaging field of view is small and the application range is limited, the present invention provides a magnetic field based on non-uniform excitation field A nanoparticle imaging method, the method comprising:

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